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Assay Detail

CHEMBL3637529

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells assessed as cell viability
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Papadopoulou MV, Bloomer WD, Rosenzweig HS, O'Shea IP, Wilkinson SR, Kaiser M.
Eur J Med Chem (2015) 103 : 325 -334
PubMed 26363868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.52 4.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3633325 1 4.70
CHEMBL3633322 1 4.66
CHEMBL3633326 1 4.50
CHEMBL3633321 1 4.22
CHEMBL3633312 1 -
CHEMBL3633313 1 -
CHEMBL3633314 1 -
CHEMBL3633315 1 -
CHEMBL3633316 1 -
CHEMBL3633317 1 -
CHEMBL3633318 1 -
CHEMBL3633319 1 -
CHEMBL3633311 1 -
CHEMBL3633323 1 -
CHEMBL3633324 1 -
CHEMBL3633327 1 -
CHEMBL3633328 1 -
CHEMBL3633320 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3633325 IC50 = 20190.0 nM 4.70
CHEMBL3633322 IC50 = 21910.0 nM 4.66
CHEMBL3633326 IC50 = 31740.0 nM 4.50
CHEMBL3633321 IC50 = 59850.0 nM 4.22
CHEMBL3633312 IC50 = 108400.0 nM -
CHEMBL3633313 IC50 = 202470.0 nM -
CHEMBL3633314 IC50 = 148480.0 nM -
CHEMBL3633315 IC50 = 132570.0 nM -
CHEMBL3633316 IC50 = 213050.0 nM -
CHEMBL3633317 IC50 = 173100.0 nM -
CHEMBL3633318 IC50 = 149690.0 nM -
CHEMBL3633319 IC50 = 279970.0 nM -
CHEMBL3633311 IC50 > 285300.0 nM -
CHEMBL3633323 IC50 = 156490.0 nM -
CHEMBL3633324 IC50 = 116280.0 nM -
CHEMBL3633327 IC50 = 212760.0 nM -
CHEMBL3633328 IC50 = 126930.0 nM -
CHEMBL3633320 IC50 = 110630.0 nM -