Assay Detail
Functional
CHEMBL3637532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei assessed as reduction in cell viability after 3 days by alamar blue assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.14 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633322 | — | — | 1 | 5.56 |
| CHEMBL3633321 | — | — | 1 | 5.45 |
| CHEMBL3633312 | — | — | 1 | 5.33 |
| CHEMBL3633313 | — | — | 1 | 4.76 |
| CHEMBL3633320 | — | — | 1 | 4.58 |
| CHEMBL3633311 | — | — | 1 | - |
| CHEMBL3633314 | — | — | 1 | - |
| CHEMBL3633318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633322 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL3633321 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL3633312 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL3633313 | — | IC50 | = | 17530.0 | nM | 4.76 |
| CHEMBL3633320 | — | IC50 | = | 26010.0 | nM | 4.58 |
| CHEMBL3633311 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3633314 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3633318 | — | IC50 | > | 30000.0 | nM | - |