Assay Detail
Functional
CHEMBL3637533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against bloodstream forms of Trypanosoma brucei brucei overexpressing type I nitroreductase assessed as reduction in cell viability after 3 days by alamar blue assay in absence of tetracycline
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.22 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633322 | — | — | 1 | 5.41 |
| CHEMBL3633321 | — | — | 1 | 5.38 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.36 |
| CHEMBL3633312 | — | — | 1 | 5.10 |
| CHEMBL3633313 | — | — | 1 | 4.87 |
| CHEMBL3633320 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633322 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL3633321 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL3633312 | — | IC50 | = | 7970.0 | nM | 5.10 |
| CHEMBL3633313 | — | IC50 | = | 13620.0 | nM | 4.87 |
| CHEMBL3633320 | — | IC50 | > | 30000.0 | nM | - |