Assay Detail
Binding
CHEMBL3637708
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged PTP1B (unknown origin) by plate reader analysis using DiFMUP as substrate
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.48 | 5.77 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3632914 | — | — | 1 | 5.77 |
| CHEMBL3633138 | — | — | 1 | 5.64 |
| CHEMBL3633139 | — | — | 1 | 5.62 |
| CHEMBL3632912 | — | — | 1 | 5.44 |
| CHEMBL1829864 | — | — | 1 | 5.21 |
| CHEMBL3632913 | — | — | 1 | 5.21 |
| CHEMBL3633140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3632914 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3633138 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3633139 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3632912 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1829864 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3632913 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3633140 | — | Ki | = | 4100000.0 | nM | - |