Assay Detail
Binding
CHEMBL3637709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged PTP-sigma (unknown origin) by plate reader analysis using DiFMUP as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase S (CHEMBL2396508) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Bidentate Salicylic Acid Inhibitors of PTP1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633138 | — | — | 1 | 6.22 |
| CHEMBL3633139 | — | — | 1 | 6.05 |
| CHEMBL1829864 | — | — | 1 | 5.37 |
| CHEMBL3632914 | — | — | 1 | 5.10 |
| CHEMBL3632913 | — | — | 1 | 4.93 |
| CHEMBL3632912 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633138 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3633139 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1829864 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3632914 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3632913 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL3632912 | — | IC50 | = | 15600.0 | nM | 4.81 |