Assay Detail
Functional
CHEMBL3637734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay
14
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.58 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3634183 | — | — | 2 | 6.30 |
| CHEMBL3634185 | — | — | 1 | 6.05 |
| CHEMBL3634186 | — | — | 1 | 6.00 |
| CHEMBL3634182 | — | — | 2 | 6.00 |
| CHEMBL3634184 | — | — | 2 | 5.96 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 5.77 |
| CHEMBL575257 | — | — | 2 | 5.35 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | 2.0 | 1 | 5.17 |
| CHEMBL335206 | — | — | 1 | 4.49 |
| CHEMBL435402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3634183 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3634185 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3634186 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3634182 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3634184 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3634183 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3634182 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL575257 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL14249 | ADENOSINE TRIPHOSPHATE | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL575257 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3634184 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL335206 | — | EC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL435402 | — | EC50 | - | — | - |