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Assay Detail

CHEMBL3637832

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
GSK_TB: Effect of compound calculated as % inhibition at single shot or pIC50 ( pIC50 ATP assay M.bovis)
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium bovis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis variant bovis (CHEMBL613086) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis variant bovis

Publication

GSK Tres Cantos Follow-up TB Screening Data.
Rebollo-Lopez, M. J.; Lelièvre, J.; Alvarez-Gomez, D.; Castro-Pichel, J.; Martínez-Jiménez, F.; Papadatos, G.; Kumar, V.; Colmenarejo, G.; Mugumbate, G.; Hurle, M.; Barroso, V.; Young, R. J.; Martinez-Hoyos, M.; González del Río, R.; Bates, R. H.; Lopez-Roman, E. M.; Mendoza-Losana, A.; Brown, J. R.; Alvarez-Ruiz, E.; Marti-Renom, M. A.; Overington, J. P.; Cammack, N.; Ballell, L.; Barros-Aguire, D.,

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 5.32 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3637787 — — 1 7.00
CHEMBL3637811 — — 1 6.10
CHEMBL3637784 — — 1 5.90
CHEMBL3637786 — — 1 5.90
CHEMBL3637795 — — 1 5.70
CHEMBL3637791 — — 1 5.70
CHEMBL3637796 — — 1 5.60
CHEMBL3637801 — — 1 5.60
CHEMBL3637823 — — 1 5.60
CHEMBL3637785 — — 1 5.60
CHEMBL3488102 — — 1 5.60
CHEMBL3637792 — — 1 5.50
CHEMBL3637804 — — 1 5.50
CHEMBL3637800 — — 1 5.50
CHEMBL3637814 — — 1 5.50
CHEMBL3637803 — — 1 5.50
CHEMBL3637802 — — 1 5.40
CHEMBL3637819 — — 1 5.40
CHEMBL3637799 — — 1 5.40
CHEMBL3637821 — — 1 5.40
CHEMBL3637806 — — 1 5.30
CHEMBL3637830 — — 1 5.30
CHEMBL3637793 — — 1 5.30
CHEMBL3637783 — — 1 5.30
CHEMBL3637788 — — 1 5.30
CHEMBL3637818 — — 1 5.30
CHEMBL3637805 — — 1 5.20
CHEMBL3637827 — — 1 5.20
CHEMBL3637813 — — 1 5.20
CHEMBL3637817 — — 1 5.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3637787 — IC50 = 100.0 nM 7.00
CHEMBL3637811 — IC50 = 794.33 nM 6.10
CHEMBL3637784 — IC50 = 1258.93 nM 5.90
CHEMBL3637786 — IC50 = 1258.93 nM 5.90
CHEMBL3637795 — IC50 = 1995.26 nM 5.70
CHEMBL3637791 — IC50 = 1995.26 nM 5.70
CHEMBL3637796 — IC50 = 2511.89 nM 5.60
CHEMBL3637801 — IC50 = 2511.89 nM 5.60
CHEMBL3637823 — IC50 = 2511.89 nM 5.60
CHEMBL3637785 — IC50 = 2511.89 nM 5.60
CHEMBL3488102 — IC50 = 2511.89 nM 5.60
CHEMBL3637814 — IC50 = 3162.28 nM 5.50
CHEMBL3637792 — IC50 = 3162.28 nM 5.50
CHEMBL3637804 — IC50 = 3162.28 nM 5.50
CHEMBL3637803 — IC50 = 3162.28 nM 5.50
CHEMBL3637800 — IC50 = 3162.28 nM 5.50
CHEMBL3637802 — IC50 = 3981.07 nM 5.40
CHEMBL3637819 — IC50 = 3981.07 nM 5.40
CHEMBL3637799 — IC50 = 3981.07 nM 5.40
CHEMBL3637821 — IC50 = 3981.07 nM 5.40
CHEMBL3637830 — IC50 = 5011.87 nM 5.30
CHEMBL3637793 — IC50 = 5011.87 nM 5.30
CHEMBL3637783 — IC50 = 5011.87 nM 5.30
CHEMBL3637806 — IC50 = 5011.87 nM 5.30
CHEMBL3637818 — IC50 = 5011.87 nM 5.30
CHEMBL3637788 — IC50 = 5011.87 nM 5.30
CHEMBL3637805 — IC50 = 6309.57 nM 5.20
CHEMBL3637827 — IC50 = 6309.57 nM 5.20
CHEMBL3637813 — IC50 = 6309.57 nM 5.20
CHEMBL3637817 — IC50 = 6309.57 nM 5.20
CHEMBL3637810 — IC50 = 6309.57 nM 5.20
CHEMBL3637815 — IC50 = 6309.57 nM 5.20
CHEMBL3637825 — IC50 = 6309.57 nM 5.20
CHEMBL3637789 — IC50 = 6309.57 nM 5.20
CHEMBL3637826 — IC50 = 6309.57 nM 5.20
CHEMBL3637829 — IC50 = 7943.28 nM 5.10
CHEMBL3637809 — IC50 = 7943.28 nM 5.10
CHEMBL3637812 — IC50 = 7943.28 nM 5.10
CHEMBL3637790 — IC50 = 7943.28 nM 5.10
CHEMBL3637820 — IC50 = 7943.28 nM 5.10
CHEMBL3637807 — IC50 = 7943.28 nM 5.10
CHEMBL3637822 — IC50 = 7943.28 nM 5.10
CHEMBL1109 SULFAPHENAZOLE IC50 = 10000.0 nM 5.00
CHEMBL3637828 — IC50 = 12589.25 nM 4.90
CHEMBL3637794 — IC50 = 12589.25 nM 4.90
CHEMBL3637797 — IC50 = 12589.25 nM 4.90
CHEMBL3637798 — IC50 = 15848.93 nM 4.80
CHEMBL3637808 — IC50 = 19952.62 nM 4.70
CHEMBL3637816 — IC50 = 19952.62 nM 4.70
CHEMBL3637824 — IC50 = 25118.86 nM 4.60