Assay Detail
Functional
CHEMBL3638124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in human HEK293 cells transfected with rabbit L-type calcium channel subunits
1
Total Activities
1
Compounds Tested
1
Activity Types
6
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
L-type calcium channel alpha 1C/beta 2A (CHEMBL3638171) ↗| Type | PROTEIN COMPLEX |
| Organism | Oryctolagus cuniculus |
Publication
IC50 data for the L-type calcium channel extracted from a set of literature articles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.70 | 4.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| CA_SOL_CONC | CA_SOL_CONC | 5.0 | mM | — |
| DETECTION_METHOD | DETECTION_METHOD | - | — | Whole cell patch clamp |
| HOLDING_POTENTIAL | HOLDING_POTENTIAL | - | — | -80 |
| MEAS_VOLT | MEAS_VOLT | - | mV | — |
| T1_PULSE | T1_PULSE | 0.1 | s | — |
| TEMP | TEMP | - | — | room |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261491 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261491 | — | IC50 | = | 20000.0 | nM | 4.70 |