Assay Detail
Functional
CHEMBL3638153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig atrial myocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
6
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Cell Type | Cardiac Muscle Cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1C (CHEMBL2366456) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
IC50 data for the L-type calcium channel extracted from a set of literature articles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.55 | 6.55 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| CA_SOL_CONC | CA_SOL_CONC | 2.0 | mM | — |
| DETECTION_METHOD | DETECTION_METHOD | - | — | Whole cell patch clamp |
| HOLDING_POTENTIAL | HOLDING_POTENTIAL | - | — | -40 |
| MEAS_VOLT | MEAS_VOLT | 10.0 | mV | — |
| T1_PULSE | T1_PULSE | 0.2 | s | — |
| TEMP | TEMP | - | — | 22 pm 1 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441 | THIOPENTAL | 4.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441 | THIOPENTAL | IC50 | = | 280.0 | nM | 6.55 |