Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3705047

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition Assay: Inhibition assay using TNF-alpha.
ChEMBL ↗
577
Total Activities
289
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tumor necrosis factor (CHEMBL1825) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Compounds for the treatment of inflammatory disorders
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 289 6.32 7.70
Ki 288 9.33 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3642435 — — 2 10.52
CHEMBL3640299 — — 2 10.52
CHEMBL3640298 — — 2 10.28
CHEMBL3640339 — — 2 10.28
CHEMBL3640336 — — 2 10.25
CHEMBL3642459 — — 2 10.22
CHEMBL3640352 — — 2 10.20
CHEMBL3642501 — — 2 10.20
CHEMBL3640337 — — 2 10.19
CHEMBL3642496 — — 2 10.14
CHEMBL1288000 — — 2 10.13
CHEMBL3640370 — — 2 10.12
CHEMBL3640366 — — 2 10.11
CHEMBL3640367 — — 2 10.11
CHEMBL3642511 — — 2 10.08
CHEMBL3640368 — — 2 10.08
CHEMBL3642499 — — 2 10.03
CHEMBL3642508 — — 2 10.03
CHEMBL1288726 — — 2 10.01
CHEMBL3640351 — — 2 10.01
CHEMBL3642518 — — 2 10.00
CHEMBL3640417 — — 2 9.96
CHEMBL3642500 — — 2 9.96
CHEMBL3642528 — — 2 9.96
CHEMBL3640353 — — 2 9.94
CHEMBL3640402 — — 2 9.92
CHEMBL3642513 — — 2 9.92
CHEMBL3642514 — — 2 9.92
CHEMBL3642527 — — 2 9.92
CHEMBL3640401 — — 2 9.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3642435 — Ki = 0.03 nM 10.52
CHEMBL3640299 — Ki = 0.03 nM 10.52
CHEMBL3640298 — Ki = 0.0521 nM 10.28
CHEMBL3640339 — Ki = 0.0524 nM 10.28
CHEMBL3640336 — Ki = 0.0556 nM 10.25
CHEMBL3642459 — Ki = 0.06 nM 10.22
CHEMBL3640352 — Ki = 0.0627 nM 10.20
CHEMBL3642501 — Ki = 0.063 nM 10.20
CHEMBL3640337 — Ki = 0.0651 nM 10.19
CHEMBL3642496 — Ki = 0.072 nM 10.14
CHEMBL1288000 — Ki = 0.074 nM 10.13
CHEMBL3640370 — Ki = 0.0762 nM 10.12
CHEMBL3640367 — Ki = 0.077 nM 10.11
CHEMBL3640366 — Ki = 0.0781 nM 10.11
CHEMBL3642511 — Ki = 0.083 nM 10.08
CHEMBL3640368 — Ki = 0.0826 nM 10.08
CHEMBL3642508 — Ki = 0.093 nM 10.03
CHEMBL3642499 — Ki = 0.093 nM 10.03
CHEMBL3640351 — Ki = 0.0973 nM 10.01
CHEMBL1288726 — Ki = 0.0988 nM 10.01
CHEMBL3642518 — Ki = 0.1 nM 10.00
CHEMBL3640417 — Ki = 0.11 nM 9.96
CHEMBL3642500 — Ki = 0.11 nM 9.96
CHEMBL3642528 — Ki = 0.11 nM 9.96
CHEMBL3640353 — Ki = 0.115 nM 9.94
CHEMBL3640402 — Ki = 0.12 nM 9.92
CHEMBL3642527 — Ki = 0.12 nM 9.92
CHEMBL3642514 — Ki = 0.12 nM 9.92
CHEMBL3642513 — Ki = 0.12 nM 9.92
CHEMBL3642509 — Ki = 0.13 nM 9.89
CHEMBL3640401 — Ki = 0.13 nM 9.89
CHEMBL3642447 — Ki = 0.15 nM 9.82
CHEMBL3642457 — Ki = 0.15 nM 9.82
CHEMBL3642502 — Ki = 0.15 nM 9.82
CHEMBL3642490 — Ki = 0.16 nM 9.80
CHEMBL3642491 — Ki = 0.16 nM 9.80
CHEMBL3642476 — Ki = 0.16 nM 9.80
CHEMBL3642442 — Ki = 0.16 nM 9.80
CHEMBL3642463 — Ki = 0.17 nM 9.77
CHEMBL3642485 — Ki = 0.17 nM 9.77
CHEMBL3640408 — Ki = 0.17 nM 9.77
CHEMBL3642512 — Ki = 0.17 nM 9.77
CHEMBL3642495 — Ki = 0.18 nM 9.74
CHEMBL3642517 — Ki = 0.18 nM 9.74
CHEMBL3642488 — Ki = 0.18 nM 9.74
CHEMBL3640406 — Ki = 0.18 nM 9.74
CHEMBL3640391 — Ki = 0.18 nM 9.74
CHEMBL3642552 — Ki = 0.19 nM 9.72
CHEMBL3640386 — Ki = 0.19 nM 9.72
CHEMBL3642548 — Ki = 0.19 nM 9.72