Assay Detail
Binding
CHEMBL3705080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding Assay: The binding affinity and selectivity of candidate molecules yielded from database screening were determined by a fluorescent polarization competitive binding assay using purified baculovirus-expressed human ER beta or ER alpha and a fluorescent estrogen ligand EL Red (PanVera Corp.).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phytoestrogenic formulations for alleviation or prevention of neurodegenerative diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.81 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | — | 1 | 7.12 |
| CHEMBL3648370 | — | — | 1 | 6.92 |
| CHEMBL192548 | — | — | 1 | 5.63 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 5.33 |
| CHEMBL370039 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30707 | COUMESTROL | IC50 | = | 75.7 | nM | 7.12 |
| CHEMBL3648370 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL192548 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL44 | GENISTEIN | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL370039 | — | IC50 | = | 85700.0 | nM | 4.07 |