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Assay Detail

CHEMBL3705096

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Binding
Inhibition Assay: Inhibition assay using matriptase enzyme
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 47 7.70 10.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3655686 — — 1 10.16
CHEMBL3655698 — — 1 9.31
CHEMBL3655699 — — 1 9.15
CHEMBL468270 — — 1 9.13
CHEMBL461870 — — 1 8.77
CHEMBL460810 — — 1 8.60
CHEMBL3655685 — — 1 8.38
CHEMBL453766 — — 1 8.27
CHEMBL518179 — — 1 8.27
CHEMBL460378 — — 1 8.22
CHEMBL507322 — — 1 8.21
CHEMBL498875 — — 1 8.21
CHEMBL444411 — — 1 8.20
CHEMBL3655687 — — 1 8.09
CHEMBL3655697 — — 1 7.96
CHEMBL492342 — — 1 7.93
CHEMBL499200 — — 1 7.92
CHEMBL493116 — — 1 7.92
CHEMBL499274 — — 1 7.89
CHEMBL3655694 — — 1 7.80
CHEMBL3655700 — — 1 7.66
CHEMBL3655696 — — 1 7.63
CHEMBL3655691 — — 1 7.62
CHEMBL3655688 — — 1 7.61
CHEMBL516786 — — 1 7.58
CHEMBL513007 — — 1 7.55
CHEMBL513818 — — 1 7.54
CHEMBL493936 — — 1 7.52
CHEMBL3655690 — — 1 7.51
CHEMBL493117 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3655686 — Ki = 0.069 nM 10.16
CHEMBL3655698 — Ki = 0.49 nM 9.31
CHEMBL3655699 — Ki = 0.7 nM 9.15
CHEMBL468270 — Ki = 0.74 nM 9.13
CHEMBL461870 — Ki = 1.7 nM 8.77
CHEMBL460810 — Ki = 2.5 nM 8.60
CHEMBL3655685 — Ki = 4.2 nM 8.38
CHEMBL453766 — Ki = 5.4 nM 8.27
CHEMBL518179 — Ki = 5.4 nM 8.27
CHEMBL460378 — Ki = 6.0 nM 8.22
CHEMBL507322 — Ki = 6.1 nM 8.21
CHEMBL498875 — Ki = 6.1 nM 8.21
CHEMBL444411 — Ki = 6.3 nM 8.20
CHEMBL3655687 — Ki = 8.1 nM 8.09
CHEMBL3655697 — Ki = 11.0 nM 7.96
CHEMBL492342 — Ki = 11.8 nM 7.93
CHEMBL499200 — Ki = 12.0 nM 7.92
CHEMBL493116 — Ki = 12.1 nM 7.92
CHEMBL499274 — Ki = 13.0 nM 7.89
CHEMBL3655694 — Ki = 16.0 nM 7.80
CHEMBL3655700 — Ki = 21.8 nM 7.66
CHEMBL3655696 — Ki = 23.5 nM 7.63
CHEMBL3655691 — Ki = 24.0 nM 7.62
CHEMBL3655688 — Ki = 24.5 nM 7.61
CHEMBL516786 — Ki = 26.0 nM 7.58
CHEMBL513007 — Ki = 28.0 nM 7.55
CHEMBL513818 — Ki = 29.0 nM 7.54
CHEMBL493936 — Ki = 30.5 nM 7.52
CHEMBL3655690 — Ki = 31.0 nM 7.51
CHEMBL493117 — Ki = 32.0 nM 7.50
CHEMBL493118 — Ki = 36.0 nM 7.44
CHEMBL3655693 — Ki = 44.5 nM 7.35
CHEMBL468895 — Ki = 47.0 nM 7.33
CHEMBL3655701 — Ki = 54.0 nM 7.27
CHEMBL459525 — Ki = 56.0 nM 7.25
CHEMBL468894 — Ki = 60.0 nM 7.22
CHEMBL523865 — Ki = 65.0 nM 7.19
CHEMBL3655695 — Ki = 87.0 nM 7.06
CHEMBL466588 — Ki = 91.0 nM 7.04
CHEMBL3655689 — Ki = 98.0 nM 7.01
CHEMBL461655 — Ki = 100.0 nM 7.00
CHEMBL513339 — Ki = 117.0 nM 6.93
CHEMBL3655702 — Ki = 130.0 nM 6.89
CHEMBL466585 — Ki = 145.0 nM 6.84
CHEMBL3655703 — Ki = 246.0 nM 6.61
CHEMBL495143 — Ki = 255.0 nM 6.59
CHEMBL3655692 — Ki = 24000.0 nM 4.62