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Assay Detail

CHEMBL3705148

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding Assay: Radioligand binding assay: The radioligand [3H]-rac-2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline was used at a concentration equal to the calculated Kd value of 60 nM to give a total binding at around 0.1% of the total added radioligand concentration, and a specific binding which represented approximately 70-80% of the total binding.
ChEMBL ↗
104
Total Activities
103
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Trace amine-associated receptor 1 (CHEMBL4908) ↗
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Aminomethyl-4-imidazoles
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 104 8.52 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3645385 — — 1 9.05
CHEMBL2206377 — — 1 9.00
CHEMBL3645461 — — 1 9.00
CHEMBL3645460 — — 1 9.00
CHEMBL3645456 — — 1 9.00
CHEMBL3645454 — — 1 9.00
CHEMBL2206385 — — 1 9.00
CHEMBL3645451 — — 1 9.00
CHEMBL3645449 — — 1 9.00
CHEMBL3645440 — — 1 9.00
CHEMBL3645439 — — 1 9.00
CHEMBL3645437 — — 1 9.00
CHEMBL3645434 — — 1 9.00
CHEMBL3645433 — — 1 9.00
CHEMBL3645423 — — 1 9.00
CHEMBL3645447 — — 1 9.00
CHEMBL3645393 — — 1 8.96
CHEMBL3645397 — — 1 8.92
CHEMBL2206376 — — 1 8.92
CHEMBL2206890 — — 1 8.92
CHEMBL2206384 — — 1 8.89
CHEMBL3645388 — — 1 8.85
CHEMBL3645389 — — 1 8.85
CHEMBL3645422 — — 1 8.85
CHEMBL3645387 — — 1 8.82
CHEMBL3645410 — — 1 8.82
CHEMBL3642845 — — 1 8.74
CHEMBL3645431 — — 1 8.70
CHEMBL3645435 — — 1 8.70
CHEMBL3645444 — — 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3645385 — Ki = 0.9 nM 9.05
CHEMBL3645454 — Ki = 1.0 nM 9.00
CHEMBL3645460 — Ki = 1.0 nM 9.00
CHEMBL3645461 — Ki = 1.0 nM 9.00
CHEMBL3645456 — Ki = 1.0 nM 9.00
CHEMBL2206385 — Ki = 1.0 nM 9.00
CHEMBL3645451 — Ki = 1.0 nM 9.00
CHEMBL3645449 — Ki = 1.0 nM 9.00
CHEMBL3645447 — Ki = 1.0 nM 9.00
CHEMBL2206377 — Ki = 1.0 nM 9.00
CHEMBL3645440 — Ki = 1.0 nM 9.00
CHEMBL3645439 — Ki = 1.0 nM 9.00
CHEMBL3645437 — Ki = 1.0 nM 9.00
CHEMBL3645434 — Ki = 1.0 nM 9.00
CHEMBL3645433 — Ki = 1.0 nM 9.00
CHEMBL3645423 — Ki = 1.0 nM 9.00
CHEMBL3645393 — Ki = 1.1 nM 8.96
CHEMBL2206890 — Ki = 1.2 nM 8.92
CHEMBL2206376 — Ki = 1.2 nM 8.92
CHEMBL3645397 — Ki = 1.2 nM 8.92
CHEMBL2206384 — Ki = 1.3 nM 8.89
CHEMBL3645422 — Ki = 1.4 nM 8.85
CHEMBL3645388 — Ki = 1.4 nM 8.85
CHEMBL3645389 — Ki = 1.4 nM 8.85
CHEMBL3645410 — Ki = 1.5 nM 8.82
CHEMBL3645387 — Ki = 1.5 nM 8.82
CHEMBL3642845 — Ki = 1.8 nM 8.74
CHEMBL3645446 — Ki = 2.0 nM 8.70
CHEMBL3645444 — Ki = 2.0 nM 8.70
CHEMBL3645435 — Ki = 2.0 nM 8.70
CHEMBL3645431 — Ki = 2.0 nM 8.70
CHEMBL3639443 — Ki = 2.0 nM 8.70
CHEMBL3645452 — Ki = 2.0 nM 8.70
CHEMBL3645453 — Ki = 2.0 nM 8.70
CHEMBL3645458 — Ki = 2.0 nM 8.70
CHEMBL3645457 — Ki = 2.0 nM 8.70
CHEMBL3645459 — Ki = 2.0 nM 8.70
CHEMBL3645404 — Ki = 2.1 nM 8.68
CHEMBL3645382 — Ki = 2.3 nM 8.64
CHEMBL3645406 — Ki = 2.3 nM 8.64
CHEMBL3645421 — Ki = 2.4 nM 8.62
CHEMBL2206388 — Ki = 2.4 nM 8.62
CHEMBL3645415 — Ki = 2.5 nM 8.60
CHEMBL3645417 — Ki = 2.6 nM 8.59
CHEMBL3645384 — Ki = 2.8 nM 8.55
CHEMBL3645427 — Ki = 2.8 nM 8.55
CHEMBL3642844 — Ki = 2.9 nM 8.54
CHEMBL3645450 — Ki = 3.0 nM 8.52
CHEMBL3645398 — Ki = 3.0 nM 8.52
CHEMBL3645432 — Ki = 3.0 nM 8.52