Assay Detail
Binding
CHEMBL3705149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted indole compounds having NOS inhibitory activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 5.81 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1852332 | — | — | 1 | 6.70 |
| CHEMBL1852338 | — | — | 1 | 6.66 |
| CHEMBL1852428 | — | — | 1 | 6.58 |
| CHEMBL1852773 | — | — | 1 | 6.50 |
| CHEMBL3645466 | — | — | 1 | 6.39 |
| CHEMBL3645479 | — | — | 1 | 6.37 |
| CHEMBL1852369 | — | — | 1 | 6.31 |
| CHEMBL3645472 | — | — | 1 | 6.31 |
| CHEMBL1852460 | — | — | 1 | 6.23 |
| CHEMBL1852621 | — | — | 1 | 6.16 |
| CHEMBL3645482 | — | — | 1 | 6.16 |
| CHEMBL3645471 | — | — | 1 | 6.14 |
| CHEMBL3645476 | — | — | 1 | 6.09 |
| CHEMBL3645475 | — | — | 1 | 6.08 |
| CHEMBL1852496 | — | — | 1 | 6.06 |
| CHEMBL1963527 | — | — | 1 | 6.04 |
| CHEMBL3645483 | — | — | 1 | 6.01 |
| CHEMBL1852597 | — | — | 1 | 6.00 |
| CHEMBL3645484 | — | — | 1 | 5.98 |
| CHEMBL1852610 | — | — | 1 | 5.92 |
| CHEMBL1963179 | — | — | 1 | 5.92 |
| CHEMBL3645480 | — | — | 1 | 5.91 |
| CHEMBL1852462 | — | — | 1 | 5.91 |
| CHEMBL1852455 | — | — | 1 | 5.85 |
| CHEMBL2079439 | — | — | 1 | 5.76 |
| CHEMBL1963528 | — | — | 1 | 5.75 |
| CHEMBL1852328 | — | — | 1 | 5.75 |
| CHEMBL1963529 | — | — | 1 | 5.73 |
| CHEMBL1852588 | — | — | 1 | 5.71 |
| CHEMBL3645465 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1852332 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1852338 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1852428 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1852773 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3645466 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3645479 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1852369 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3645472 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1852460 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1852621 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3645482 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3645471 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL3645476 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3645475 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1852496 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1963527 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3645483 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1852597 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3645484 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL1852610 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1963179 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL3645480 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1852462 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL1852455 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2079439 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL1963528 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1852328 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1963529 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL1852588 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3645465 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3645477 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL3645470 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1963156 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL1963168 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL3645489 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1852404 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3645468 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL3645478 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL3645464 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3645485 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1852524 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL3645486 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL2079330 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3645474 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL3645481 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL3645487 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL1963535 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3645469 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL3645473 | — | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL3645488 | — | IC50 | = | 12000.0 | nM | 4.92 |