Assay Detail
Binding
CHEMBL3705561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: Inhibition of human C1s was determined by the method described in [0092]-[0098] using native human activated C1s complement component from Calbiochem at 29 nM and Val-Ser-Arg-pNA (S2314) at 8 mM, 6 mM, and 4 mM as substrate; results are reported as Ki values (nanomolar).
23
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Trypsin-like serine protease inhibitors, and their preparation and use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.18 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3660171 | — | — | 1 | 5.92 |
| CHEMBL3660179 | — | — | 1 | 5.70 |
| CHEMBL3660188 | — | — | 1 | 5.38 |
| CHEMBL3660190 | — | — | 1 | 5.32 |
| CHEMBL3660191 | — | — | 1 | 5.30 |
| CHEMBL3660189 | — | — | 1 | 5.19 |
| CHEMBL3660173 | — | — | 1 | 5.10 |
| CHEMBL3660176 | — | — | 1 | 5.05 |
| CHEMBL3660184 | — | — | 2 | 5.02 |
| CHEMBL3660180 | — | — | 1 | 4.89 |
| CHEMBL3660174 | — | — | 1 | 4.72 |
| CHEMBL3660178 | — | — | 1 | 4.70 |
| CHEMBL3660175 | — | — | 1 | - |
| CHEMBL3660177 | — | — | 1 | - |
| CHEMBL3660181 | — | — | 1 | - |
| CHEMBL3660182 | — | — | 1 | - |
| CHEMBL3660183 | — | — | 1 | - |
| CHEMBL3660185 | — | — | 2 | - |
| CHEMBL3660186 | — | — | 1 | - |
| CHEMBL3660172 | — | — | 1 | - |
| CHEMBL3660192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3660171 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3660179 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL3660188 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL3660190 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL3660191 | — | Ki | = | 4950.0 | nM | 5.30 |
| CHEMBL3660189 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL3660173 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL3660176 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL3660184 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL3660184 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL3660180 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL3660174 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL3660178 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3660172 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3660181 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL3660182 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3660183 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3660185 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3660186 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL3660192 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3660185 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3660177 | — | Ki | > | 25000.0 | nM | - |
| CHEMBL3660175 | — | Ki | > | 25000.0 | nM | - |