Assay Detail
Binding
CHEMBL3707605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and phosphatidyl inositol in the assay are 5 μM and 6 μg/mL, respectively. The reaction is started by the addition of PI3 kinase, e.g. PI3 kinase δ. Refer to the patent for more info.
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tetrahydro-pyrido-pyrimidine derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 7.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3643428 | — | — | 1 | 8.52 |
| CHEMBL3643417 | — | — | 1 | 8.52 |
| CHEMBL3643415 | — | — | 1 | 8.52 |
| CHEMBL3643420 | — | — | 1 | 8.40 |
| CHEMBL3643418 | — | — | 1 | 8.40 |
| CHEMBL3643375 | — | — | 1 | 8.40 |
| CHEMBL3643421 | — | — | 1 | 8.40 |
| CHEMBL3643419 | — | — | 1 | 8.40 |
| CHEMBL3643401 | — | — | 1 | 8.30 |
| CHEMBL3643400 | — | — | 1 | 8.30 |
| CHEMBL3643399 | — | — | 1 | 8.22 |
| CHEMBL3643416 | — | — | 1 | 8.22 |
| CHEMBL3643387 | — | — | 1 | 8.22 |
| CHEMBL3643422 | — | — | 1 | 8.15 |
| CHEMBL3643414 | — | — | 1 | 8.15 |
| CHEMBL3643369 | — | — | 1 | 8.10 |
| CHEMBL3643370 | — | — | 1 | 8.10 |
| CHEMBL3643386 | — | — | 1 | 8.05 |
| CHEMBL3643357 | — | — | 1 | 8.05 |
| CHEMBL3643358 | — | — | 1 | 8.05 |
| CHEMBL3643430 | — | — | 1 | 8.05 |
| CHEMBL3643350 | — | — | 1 | 8.05 |
| CHEMBL3643372 | — | — | 1 | 8.05 |
| CHEMBL3643438 | — | — | 1 | 8.05 |
| CHEMBL3643371 | — | — | 1 | 8.00 |
| CHEMBL3643359 | — | — | 1 | 7.96 |
| CHEMBL3643437 | — | — | 1 | 7.96 |
| CHEMBL3643376 | — | — | 1 | 7.96 |
| CHEMBL3643424 | — | — | 1 | 7.92 |
| CHEMBL3643407 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3643428 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3643417 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3643415 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3643420 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3643418 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3643375 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3643421 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3643419 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3643401 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3643400 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3643399 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3643416 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3643387 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3643422 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3643414 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3643369 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3643370 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3643386 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643357 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643358 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643430 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643350 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643372 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643438 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3643371 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3643359 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3643376 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3643437 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3643424 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3643407 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3643360 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3643433 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3643362 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3643402 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3643355 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3643361 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3643389 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3643381 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3643363 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3643412 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3643388 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3643351 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3643349 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3643385 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643426 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643390 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643391 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643364 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3643425 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3643429 | — | IC50 | = | 17.0 | nM | 7.77 |