Compound Detail
CHEMBL3643376
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COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCOC(C)(C)C5)C4)c3C2)cc1C#N
Basic Information
| ChEMBL ID | CHEMBL3643376 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AHWQQFDZXJOJLB-OZBJMMHXSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
492.6
MW (Da)
2.50
ALogP
9
HBA
0
HBD
113.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 5.59 | 5.59 | 2585.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 11.0 | nM | 7.96 | Enzyme Assay: Test of Lipid Kinase Activity: The kinase reaction is performed in... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 2585.0 | nM | 5.59 | Enzyme Assay: Test of Lipid Kinase Activity: The kinase reaction is performed in... | - |
Data from ChEMBL 36 via Core Engine