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Assay Detail

CHEMBL3707679

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Binding
Inhibition Assay: Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known (see., e.g., National Committee for Clinical Laboratory Standards 2000 Performance standards for antimicrobial disk susceptibility tests: approved standard, 7th ed. M2-A7, vol. 20, no. 1, Committee for Clinical Laboratory Standards, Wayne, Pa.).
ChEMBL ↗
41
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dihydrofolate reductase (CHEMBL1681620) ↗
Type SINGLE PROTEIN
Organism Staphylococcus aureus

Publication

Dihydrofolate reductase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 41 9.62 10.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3681407 — — 1 10.96
CHEMBL3128014 — — 2 10.96
CHEMBL3128026 — — 1 10.92
CHEMBL3681408 — — 1 10.72
CHEMBL1818127 — — 1 10.70
CHEMBL3681412 — — 1 10.68
CHEMBL3127912 — — 1 10.66
CHEMBL1818129 — — 1 10.60
CHEMBL1818128 — — 1 10.59
CHEMBL3128013 — — 1 10.52
CHEMBL3686068 — — 1 10.41
CHEMBL3686071 — — 1 9.96
CHEMBL3681406 — — 1 9.92
CHEMBL3127916 — — 1 9.85
CHEMBL3681414 — — 1 9.80
CHEMBL3686070 — — 1 9.70
CHEMBL3681411 — — 1 9.40
CHEMBL1818120 — — 1 9.32
CHEMBL3681404 — — 1 9.30
CHEMBL3681401 — — 1 9.29
CHEMBL3127917 — — 1 9.22
CHEMBL3681400 — — 1 9.21
CHEMBL3681403 — — 1 9.19
CHEMBL3681399 — — 1 9.18
CHEMBL3681410 — — 1 9.14
CHEMBL1818110 — — 1 9.05
CHEMBL3681413 — — 1 9.04
CHEMBL3681402 — — 1 8.92
CHEMBL3686069 — — 1 8.85
CHEMBL3681405 — — 1 8.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3128014 — Ki = 0.011 nM 10.96
CHEMBL3681407 — Ki = 0.011 nM 10.96
CHEMBL3128026 — Ki = 0.012 nM 10.92
CHEMBL3128014 — Ki = 0.016 nM 10.80
CHEMBL3681408 — Ki = 0.019 nM 10.72
CHEMBL1818127 — Ki = 0.02 nM 10.70
CHEMBL3681412 — Ki = 0.021 nM 10.68
CHEMBL3127912 — Ki = 0.022 nM 10.66
CHEMBL1818129 — Ki = 0.025 nM 10.60
CHEMBL1818128 — Ki = 0.026 nM 10.59
CHEMBL3128013 — Ki = 0.03 nM 10.52
CHEMBL3686068 — Ki = 0.039 nM 10.41
CHEMBL3686071 — Ki = 0.11 nM 9.96
CHEMBL3681406 — Ki = 0.12 nM 9.92
CHEMBL3127916 — Ki = 0.14 nM 9.85
CHEMBL3681414 — Ki = 0.16 nM 9.80
CHEMBL3686070 — Ki = 0.2 nM 9.70
CHEMBL3681411 — Ki = 0.4 nM 9.40
CHEMBL1818120 — Ki = 0.48 nM 9.32
CHEMBL3681404 — Ki = 0.5 nM 9.30
CHEMBL3681401 — Ki = 0.51 nM 9.29
CHEMBL3127917 — Ki = 0.6 nM 9.22
CHEMBL3681400 — Ki = 0.61 nM 9.21
CHEMBL3681403 — Ki = 0.65 nM 9.19
CHEMBL3681399 — Ki = 0.66 nM 9.18
CHEMBL3681410 — Ki = 0.72 nM 9.14
CHEMBL1818110 — Ki = 0.89 nM 9.05
CHEMBL3681413 — Ki = 0.91 nM 9.04
CHEMBL3681402 — Ki = 1.2 nM 8.92
CHEMBL3686069 — Ki = 1.4 nM 8.85
CHEMBL3681405 — Ki = 1.6 nM 8.80
CHEMBL3681409 — Ki = 2.6 nM 8.59
CHEMBL1818113 — Ki = 2.7 nM 8.57
CHEMBL1818109 — Ki = 2.7 nM 8.57
CHEMBL3681398 — Ki = 4.0 nM 8.40
CHEMBL1818119 — Ki = 4.4 nM 8.36
CHEMBL3681397 — Ki = 15.3 nM 7.82
CHEMBL3128023 — Ki = 0.007 nM -
CHEMBL3128021 — Ki = 0.002 nM -
CHEMBL3128025 — Ki = 0.005 nM -
CHEMBL3686067 — Ki = 0.005 nM -