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Assay Detail

CHEMBL3707729

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding Assay: Binding assay using melatonin receptors 1 or 2.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Melatonin receptor type 1B (CHEMBL1946)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tricyclic compound and pharmaceutical use thereof
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 9.40 10.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3648359 1 10.31
CHEMBL3648361 1 10.04
CHEMBL3648363 1 9.92
CHEMBL3648356 1 9.89
CHEMBL3648369 1 9.85
CHEMBL4114700 1 9.66
CHEMBL4115681 1 9.66
CHEMBL3648350 1 9.62
CHEMBL3648358 1 9.55
CHEMBL3648362 1 9.55
CHEMBL3648367 1 9.55
CHEMBL3648354 1 9.51
CHEMBL3648355 1 9.51
CHEMBL4114658 1 9.43
CHEMBL3648365 1 9.39
CHEMBL4114715 1 9.37
CHEMBL3648366 1 9.12
CHEMBL3648368 1 9.11
CHEMBL3648360 1 8.21
CHEMBL3648364 1 8.07
CHEMBL3648357 1 8.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3648359 IC50 = 0.049 nM 10.31
CHEMBL3648361 IC50 = 0.091 nM 10.04
CHEMBL3648363 IC50 = 0.12 nM 9.92
CHEMBL3648356 IC50 = 0.13 nM 9.89
CHEMBL3648369 IC50 = 0.14 nM 9.85
CHEMBL4114700 IC50 = 0.22 nM 9.66
CHEMBL4115681 IC50 = 0.22 nM 9.66
CHEMBL3648350 IC50 = 0.24 nM 9.62
CHEMBL3648358 IC50 = 0.28 nM 9.55
CHEMBL3648362 IC50 = 0.28 nM 9.55
CHEMBL3648367 IC50 = 0.28 nM 9.55
CHEMBL3648354 IC50 = 0.31 nM 9.51
CHEMBL3648355 IC50 = 0.31 nM 9.51
CHEMBL4114658 IC50 = 0.37 nM 9.43
CHEMBL3648365 IC50 = 0.41 nM 9.39
CHEMBL4114715 IC50 = 0.43 nM 9.37
CHEMBL3648366 IC50 = 0.75 nM 9.12
CHEMBL3648368 IC50 = 0.77 nM 9.11
CHEMBL3648360 IC50 = 6.2 nM 8.21
CHEMBL3648364 IC50 = 8.5 nM 8.07
CHEMBL3648357 IC50 = 9.6 nM 8.02