Assay Detail
Binding
CHEMBL3707755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-TOF MS—for assay details, see reference (Greis et al., 2006).
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Prolyl hydroxylase inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.80 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3646220 | — | — | 1 | 7.08 |
| CHEMBL3646215 | — | — | 1 | 6.75 |
| CHEMBL3646222 | — | — | 1 | 6.41 |
| CHEMBL3646221 | VADADUSTAT | 4.0 | 1 | 6.41 |
| CHEMBL3646219 | — | — | 1 | 6.25 |
| CHEMBL3646227 | — | — | 1 | 5.89 |
| CHEMBL3646212 | — | — | 1 | 4.67 |
| CHEMBL3646218 | — | — | 1 | 4.43 |
| CHEMBL3646217 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3646220 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3646215 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3646222 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3646221 | VADADUSTAT | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3646219 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3646227 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3646212 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL3646218 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL3646217 | — | IC50 | = | 52300.0 | nM | 4.28 |