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Target Snapshot

CHEMBL5705 Target Snapshot

Prolyl hydroxylase EGLN3 · SINGLE PROTEIN · Homo sapiens

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177Compounds
43Assays
1Approved Drugs
224.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Prolyl hydroxylase EGLN3 shows approved-linked disease relevance led by anemia (phenotype). 3 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9H6Z9. Start with anemia (phenotype), then reuse UniProt Q9H6Z9 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with anemia (phenotype), then reuse UniProt Q9H6Z9 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
anemia (phenotype)

Prolyl hydroxylase EGLN3 shows approved-linked disease relevance led by anemia (phenotype). 3 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with anemia (phenotype) because it currently carries approved-linked support. Linked drugs include MOLIDUSTAT, VADADUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prolyl hydroxylase EGLN3 as ChEMBL target CHEMBL5705, mapped to UniProt Q9H6Z9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prolyl hydroxylase EGLN3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL5705
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9H6Z9
Prolyl hydroxylase EGLN3
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Prolyl hydroxylase EGLN3 is the right protein anchor across sources, using UniProt Q9H6Z9 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why anemia (phenotype) is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProlyl hydroxylase EGLN3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9H6Z9
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProlyl hydroxylase EGLN3
UniProt AccessionQ9H6Z9
Component TypeProtein
Sequence Length239 aa

Prolyl hydroxylase EGLN3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Prolyl hydroxylase EGLN3, mapped to UniProt Q9H6Z9. Sequence length is 239 aa.

Mapped IDQ9H6Z9
Review nameProlyl hydroxylase EGLN3
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Prolyl hydroxylase EGLN3 shows approved-linked disease relevance led by anemia (phenotype). 3 more disease programs remain visible in the same review block.

Approved-linked Approved
anemia (phenotype)
2 linked drugs · 2 direct · 2 efficacy
Linked drugMOLIDUSTAT
Linked drugVADADUSTAT
Approved-linked Approved
anemia
1 linked drug · 1 direct · 1 efficacy
Linked drugVADADUSTAT
Approved-linked Approved
chronic kidney disease
1 linked drug · 1 direct · 1 efficacy
Linked drugVADADUSTAT
Clinical signal Phase I
liver disease
1 linked drug · 1 direct · 1 efficacy
Linked drugVADADUSTAT
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with anemia (phenotype) because it currently carries approved-linked support. Linked drugs include MOLIDUSTAT, VADADUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseanemia (phenotype)
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50194.0
KI2.0
EC5012.0
KD16.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3133890 10.85 Kd 0.0142 Preclinical
CHEMBL3133889 10.82 Kd 0.0152 Preclinical
CHEMBL3133891 10.69 Kd 0.0202 Preclinical
CHEMBL20724 10.26 Kd 0.0544 Preclinical
CHEMBL3133888 10.11 Kd 0.0784 Preclinical
CHEMBL3133892 10.08 Kd 0.0834 Preclinical
CHEMBL3115284 9.1 IC50 0.8 Preclinical
CHEMBL3115283 9.1 IC50 0.8 Preclinical
CHEMBL3115282 9.1 IC50 0.8 Preclinical
CHEMBL2041190 9.1 IC50 0.8 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
8
5.5
28
6.0
11
6.5
26
7.0
25
7.5
28
8.0
11
8.5
16
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VADADUSTAT
CHEMBL3646221
Approved 2023
Properties Compare Identifier
Assay Landscape

Assay Landscape

43
Total Assays
157
Tested Compounds
1
Assay Types
Binding — 43 assays, 157 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 17 84 7.0
cell-based format 15 44 7.5
assay format 11 29 7.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine