Compound Detail
CHEMBL3133891
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Basic Information
| ChEMBL ID | CHEMBL3133891 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UNBNUHCIYLMXQH-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
213.2
MW (Da)
1.40
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.71
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 10.69
IC50 1 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl hydroxylase EGLN3 CHEMBL5705 | Kd | 10.69 | 10.69 | 0.0 | 1 |
| Prolyl hydroxylase EGLN3 CHEMBL5705 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl hydroxylase EGLN3 | Kd | = | 0.0202 | nM | 10.69 | Binding affinity to recombinant human PHD3-Fe2+ -NOG complex expressed in Escher... | - |
| Prolyl hydroxylase EGLN3 | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of recombinant human PHD3 expressed in Escherichia coli using HIF19 p... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C3MD00117B | Prolyl hydroxylase EGLN3 | 12 |
| - | 10.1039/C3MD00117B | NCI-H446 | 2 |
Data from ChEMBL 36 via Core Engine