Assay Detail
Binding
CHEMBL3707758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Enzyme Assay: The Aurora assays described here are performed on two Caliper Life Sciences systems: the LC3000 and the Desktop Profiler. These provide data on enzyme activity via measurement of the relative amounts of phosphorylated or unphosphorylated fluorescently labelled substrate peptide at the end of an enzymatic reaction. These different states of peptide are resolved by applying a potential difference across the sample. The presence of the charged phosphate group on the product (as opposed to the substrate) causes a different peptide mobility between the two peptides. This is visualized by excitation of the fluorescent label on the substrate and product peptides and represented as peaks within the analysis software.
251
Total Activities
251
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino azaheterocyclic carboxamides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 251 | 8.43 | 10.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3680444 | — | — | 1 | 10.38 |
| CHEMBL3680508 | — | — | 1 | 10.35 |
| CHEMBL3680447 | — | — | 1 | 10.34 |
| CHEMBL3680552 | — | — | 1 | 10.22 |
| CHEMBL3685243 | — | — | 1 | 10.21 |
| CHEMBL3685277 | — | — | 1 | 10.05 |
| CHEMBL3675525 | — | — | 1 | 9.77 |
| CHEMBL3685262 | — | — | 1 | 9.74 |
| CHEMBL3680596 | — | — | 1 | 9.74 |
| CHEMBL3639841 | — | — | 1 | 9.70 |
| CHEMBL3685245 | — | — | 1 | 9.68 |
| CHEMBL3685306 | — | — | 1 | 9.66 |
| CHEMBL3670499 | — | — | 1 | 9.62 |
| CHEMBL3675441 | — | — | 1 | 9.60 |
| CHEMBL3680500 | — | — | 1 | 9.59 |
| CHEMBL3680420 | — | — | 1 | 9.57 |
| CHEMBL3680554 | — | — | 1 | 9.52 |
| CHEMBL3680403 | — | — | 1 | 9.52 |
| CHEMBL3685257 | — | — | 1 | 9.51 |
| CHEMBL3675501 | — | — | 1 | 9.49 |
| CHEMBL3685237 | — | — | 1 | 9.48 |
| CHEMBL3675459 | — | — | 1 | 9.46 |
| CHEMBL3675446 | — | — | 1 | 9.46 |
| CHEMBL3670467 | — | — | 1 | 9.46 |
| CHEMBL3685250 | — | — | 1 | 9.42 |
| CHEMBL3685252 | — | — | 1 | 9.42 |
| CHEMBL3680550 | — | — | 1 | 9.42 |
| CHEMBL3680572 | — | — | 1 | 9.41 |
| CHEMBL3675444 | — | — | 1 | 9.40 |
| CHEMBL3675493 | — | — | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3680444 | — | IC50 | = | 0.042 | nM | 10.38 |
| CHEMBL3680508 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL3680447 | — | IC50 | = | 0.046 | nM | 10.34 |
| CHEMBL3680552 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL3685243 | — | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL3685277 | — | IC50 | = | 0.089 | nM | 10.05 |
| CHEMBL3675525 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3680596 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3685262 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL3639841 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3685245 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL3685306 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL3670499 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL3675441 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL3680500 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3680420 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3680403 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3680554 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3685257 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3675501 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3685237 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL3670467 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3675446 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3675459 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL3680550 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3685250 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3685252 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL3680572 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL3675444 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3675493 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3680460 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3675438 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3670485 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3680417 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3675510 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3680522 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3685249 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3680587 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3680588 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3680455 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3685272 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3670470 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3680599 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3680421 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL3680467 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL3680446 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3639742 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL3685307 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3685268 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL3675466 | — | IC50 | = | 0.66 | nM | 9.18 |