Assay Detail
Binding
CHEMBL3707911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: In vitro inhibition assay using various enzyme.
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Compound useful for the treatment of degenerative and inflammatory diseases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.84 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301607 | FILGOTINIB | 4.0 | 4 | 7.14 |
| CHEMBL3360356 | — | — | 1 | 6.90 |
| CHEMBL3360353 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 72.7 | nM | 7.14 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 73.75 | nM | 7.13 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 79.07 | nM | 7.10 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 86.77 | nM | 7.06 |
| CHEMBL3360356 | — | IC50 | = | 125.8 | nM | 6.90 |
| CHEMBL3360353 | — | IC50 | = | 2096.0 | nM | 5.68 |