Assay Detail
Binding
CHEMBL3720967
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Inhibition of Mycobacterium tuberculosis TMPK using dTMP substrate and NADH by pyruvate kinase/lactate dehydrogenase coupling system based spectrophotometric assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 4.39 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189878 | — | — | 1 | 4.91 |
| CHEMBL520293 | — | — | 1 | 4.82 |
| CHEMBL3715351 | — | — | 1 | 4.82 |
| CHEMBL193779 | — | — | 1 | 4.78 |
| CHEMBL519186 | — | — | 1 | 4.62 |
| CHEMBL3715387 | — | — | 1 | 4.58 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 4.57 |
| CHEMBL190125 | — | — | 1 | 4.50 |
| CHEMBL484514 | — | — | 1 | 4.50 |
| CHEMBL449001 | — | — | 1 | 4.48 |
| CHEMBL189057 | — | — | 1 | 4.42 |
| CHEMBL449771 | — | — | 1 | 4.38 |
| CHEMBL190912 | — | — | 1 | 4.36 |
| CHEMBL190145 | — | — | 1 | 4.36 |
| CHEMBL193948 | — | — | 1 | 4.35 |
| CHEMBL482916 | — | — | 1 | 4.33 |
| CHEMBL483334 | — | — | 1 | 4.32 |
| CHEMBL482508 | — | — | 1 | 4.32 |
| CHEMBL482509 | — | — | 1 | 4.32 |
| CHEMBL190616 | — | — | 1 | 4.30 |
| CHEMBL3716712 | — | — | 1 | 4.20 |
| CHEMBL454546 | — | — | 1 | 4.20 |
| CHEMBL189636 | — | — | 1 | 4.17 |
| CHEMBL365098 | — | — | 1 | 4.17 |
| CHEMBL3718132 | — | — | 1 | 4.16 |
| CHEMBL482510 | — | — | 1 | 4.14 |
| CHEMBL365123 | — | — | 1 | 4.12 |
| CHEMBL485322 | — | — | 1 | 4.07 |
| CHEMBL189491 | — | — | 1 | 4.05 |
| CHEMBL364887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189878 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL520293 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL3715351 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL193779 | — | Ki | = | 16500.0 | nM | 4.78 |
| CHEMBL519186 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL3715387 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL190125 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL484514 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL449001 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL189057 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL449771 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL190912 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL190145 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL193948 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL482916 | — | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL483334 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL482508 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL482509 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL190616 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL454546 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL3716712 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL189636 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL365098 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL3718132 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL482510 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL365123 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL485322 | — | Ki | = | 86000.0 | nM | 4.07 |
| CHEMBL189491 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL191010 | — | Ki | = | 265000.0 | nM | - |
| CHEMBL363794 | — | Ki | - | — | - | |
| CHEMBL365266 | — | Ki | - | — | - | |
| CHEMBL189268 | — | Ki | - | — | - | |
| CHEMBL414848 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL373302 | — | Ki | = | 810000.0 | nM | - |
| CHEMBL370674 | — | Ki | = | 980000.0 | nM | - |
| CHEMBL485122 | — | Ki | = | 139000.0 | nM | - |
| CHEMBL482520 | — | Ki | = | 119000.0 | nM | - |
| CHEMBL3719386 | — | Ki | - | — | - | |
| CHEMBL190856 | — | Ki | - | — | - | |
| CHEMBL3718858 | — | Ki | = | 113000.0 | nM | - |
| CHEMBL364887 | — | Ki | = | 110000.0 | nM | - |