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Assay Detail

CHEMBL3721195

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity against human P2X2/3 receptor expressed in CHOK1 cells assessed as inhibition of alpha,beta-meATP-induced calcium response incubated for 20 mins by Fluo-3AM dye based FLIPR assay
ChEMBL ↗
42
Total Activities
42
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO-K1
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

P2X2/P2X3 heterotrimeric receptor (CHEMBL3831281) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Diaminopyrimidines as P2X3 and P2X2/3 modulators
(2009)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Inhibition 41 - -
IC50 1 7.99 7.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3717153 — — 1 7.99
CHEMBL3718782 — — 1 -
CHEMBL3716919 — — 1 -
CHEMBL3717509 — — 1 -
CHEMBL3716122 — — 1 -
CHEMBL3717788 — — 1 -
CHEMBL3716110 — — 1 -
CHEMBL3719383 — — 1 -
CHEMBL3716939 — — 1 -
CHEMBL3715200 — — 1 -
CHEMBL3715486 — — 1 -
CHEMBL3718193 — — 1 -
CHEMBL3715500 — — 1 -
CHEMBL3715946 — — 1 -
CHEMBL3717172 — — 1 -
CHEMBL3716526 — — 1 -
CHEMBL3718862 — — 1 -
CHEMBL3715214 — — 1 -
CHEMBL3716091 — — 1 -
CHEMBL3718338 — — 1 -
CHEMBL3719290 — — 1 -
CHEMBL3717248 — — 1 -
CHEMBL3717519 — — 1 -
CHEMBL3715799 — — 1 -
CHEMBL3714982 — — 1 -
CHEMBL3718045 — — 1 -
CHEMBL3718035 — — 1 -
CHEMBL3719000 — — 1 -
CHEMBL3716052 — — 1 -
CHEMBL3718402 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3717153 — IC50 = 10.23 nM 7.99
CHEMBL3717766 — Inhibition - % -
CHEMBL3715200 — Inhibition - % -
CHEMBL3716939 — Inhibition - % -
CHEMBL3719383 — Inhibition - % -
CHEMBL3716110 — Inhibition - % -
CHEMBL3717788 — Inhibition - % -
CHEMBL3716122 — Inhibition - % -
CHEMBL3717509 — Inhibition - % -
CHEMBL3716919 — Inhibition - % -
CHEMBL3716593 — Inhibition - % -
CHEMBL3715486 — Inhibition - % -
CHEMBL495204 — Inhibition - % -
CHEMBL3719090 — Inhibition - % -
CHEMBL3719270 — Inhibition - % -
CHEMBL3717126 — Inhibition - % -
CHEMBL3718952 — Inhibition - % -
CHEMBL3714880 — Inhibition - % -
CHEMBL3717121 — Inhibition - % -
CHEMBL3716088 — Inhibition - % -
CHEMBL3716082 — Inhibition - % -
CHEMBL3716688 — Inhibition - % -
CHEMBL3719290 — Inhibition - % -
CHEMBL3718402 — Inhibition - % -
CHEMBL3716052 — Inhibition - % -
CHEMBL3719000 — Inhibition - % -
CHEMBL3718035 — Inhibition - % -
CHEMBL3718045 — Inhibition - % -
CHEMBL3714982 — Inhibition - % -
CHEMBL3715799 — Inhibition - % -
CHEMBL3717519 — Inhibition - % -
CHEMBL3717248 — Inhibition - % -
CHEMBL3718193 — Inhibition - % -
CHEMBL3718338 — Inhibition - % -
CHEMBL3716091 — Inhibition - % -
CHEMBL3715214 — Inhibition - % -
CHEMBL3718862 — Inhibition - % -
CHEMBL3718782 — Inhibition - % -
CHEMBL3716526 — Inhibition - % -
CHEMBL3717172 — Inhibition - % -
CHEMBL3715946 — Inhibition - % -
CHEMBL3715500 — Inhibition - % -