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Assay Detail

CHEMBL3734121

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of full-length recombinant human GST-tagged ILK1 expressed in baculovirus infected insect Hi5 cells using CKRRRLASLR-amide as substrate after 15 mins by scintillation counting analysis in presence of [gamma-32P]-ATP
ChEMBL ↗
152
Total Activities
152
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BTI-TN-5B1-4
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Integrin-linked protein kinase (CHEMBL5247) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 152 6.32 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3681007 — — 1 8.15
CHEMBL3681013 — — 1 8.00
CHEMBL3685712 — — 1 8.00
CHEMBL3685682 — — 1 7.70
CHEMBL3685727 — — 1 7.70
CHEMBL3639798 — — 1 7.70
CHEMBL3732995 — — 1 7.52
CHEMBL3681005 — — 1 7.40
CHEMBL3680995 — — 1 7.40
CHEMBL3685652 — — 1 7.40
CHEMBL3685661 — — 1 7.40
CHEMBL3681027 — — 1 7.40
CHEMBL3685631 — — 1 7.30
CHEMBL3681008 — — 1 7.30
CHEMBL3685659 — — 1 7.30
CHEMBL3681004 — — 1 7.22
CHEMBL3680994 — — 1 7.22
CHEMBL3685654 — — 1 7.22
CHEMBL3685693 — — 1 7.22
CHEMBL3680998 — — 1 7.16
CHEMBL3685656 — — 1 7.16
CHEMBL3680993 — — 1 7.16
CHEMBL3681024 — — 1 7.05
CHEMBL3685634 — — 1 7.00
CHEMBL3685684 — — 1 7.00
CHEMBL3685688 — — 1 7.00
CHEMBL3685695 — — 1 7.00
CHEMBL3685653 — — 1 7.00
CHEMBL3685713 — — 1 7.00
CHEMBL3680988 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3681007 — IC50 = 7.0 nM 8.15
CHEMBL3685712 — IC50 = 10.0 nM 8.00
CHEMBL3681013 — IC50 = 10.0 nM 8.00
CHEMBL3685682 — IC50 = 20.0 nM 7.70
CHEMBL3685727 — IC50 = 20.0 nM 7.70
CHEMBL3639798 — IC50 = 20.0 nM 7.70
CHEMBL3732995 — IC50 = 30.0 nM 7.52
CHEMBL3685652 — IC50 = 40.0 nM 7.40
CHEMBL3681005 — IC50 = 40.0 nM 7.40
CHEMBL3680995 — IC50 = 40.0 nM 7.40
CHEMBL3685661 — IC50 = 40.0 nM 7.40
CHEMBL3681027 — IC50 = 40.0 nM 7.40
CHEMBL3685659 — IC50 = 50.0 nM 7.30
CHEMBL3685631 — IC50 = 50.0 nM 7.30
CHEMBL3681008 — IC50 = 50.0 nM 7.30
CHEMBL3681004 — IC50 = 60.0 nM 7.22
CHEMBL3685654 — IC50 = 60.0 nM 7.22
CHEMBL3685693 — IC50 = 60.0 nM 7.22
CHEMBL3680994 — IC50 = 60.0 nM 7.22
CHEMBL3680998 — IC50 = 70.0 nM 7.16
CHEMBL3685656 — IC50 = 70.0 nM 7.16
CHEMBL3680993 — IC50 = 70.0 nM 7.16
CHEMBL3681024 — IC50 = 90.0 nM 7.05
CHEMBL3685684 — IC50 = 100.0 nM 7.00
CHEMBL3685688 — IC50 = 100.0 nM 7.00
CHEMBL3685653 — IC50 = 100.0 nM 7.00
CHEMBL3685713 — IC50 = 100.0 nM 7.00
CHEMBL3685634 — IC50 = 100.0 nM 7.00
CHEMBL3685695 — IC50 = 100.0 nM 7.00
CHEMBL3680988 — IC50 = 100.0 nM 7.00
CHEMBL3681009 — IC50 = 130.0 nM 6.89
CHEMBL3681006 — IC50 = 150.0 nM 6.82
CHEMBL3685701 — IC50 = 150.0 nM 6.82
CHEMBL3685692 — IC50 = 190.0 nM 6.72
CHEMBL3685658 — IC50 = 200.0 nM 6.70
CHEMBL3685669 — IC50 = 200.0 nM 6.70
CHEMBL3681014 — IC50 = 200.0 nM 6.70
CHEMBL3685635 — IC50 = 200.0 nM 6.70
CHEMBL3685668 — IC50 = 200.0 nM 6.70
CHEMBL3681022 — IC50 = 200.0 nM 6.70
CHEMBL3685729 — IC50 = 200.0 nM 6.70
CHEMBL3681025 — IC50 = 200.0 nM 6.70
CHEMBL3685664 — IC50 = 200.0 nM 6.70
CHEMBL3685673 — IC50 = 200.0 nM 6.70
CHEMBL3681010 — IC50 = 200.0 nM 6.70
CHEMBL3685657 — IC50 = 200.0 nM 6.70
CHEMBL3685715 — IC50 = 200.0 nM 6.70
CHEMBL3685681 — IC50 = 200.0 nM 6.70
CHEMBL3680986 — IC50 = 200.0 nM 6.70
CHEMBL3685628 — IC50 = 300.0 nM 6.52