Assay Detail
Functional
CHEMBL3734190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human P2X2/3 receptor expressed in HEK293/1321N1 cells assessed as inhibition of alpha,beta-meATP/ATP-induced calcium influx by Fluo-4 dye based FLIPR assay
93
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
P2X2/P2X3 heterotrimeric receptor (CHEMBL3831281) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 93 | 6.63 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3731399 | — | — | 1 | 7.92 |
| CHEMBL3732843 | — | — | 1 | 7.72 |
| CHEMBL3728821 | — | — | 1 | 7.72 |
| CHEMBL3730913 | — | — | 1 | 7.70 |
| CHEMBL3731410 | — | — | 1 | 7.62 |
| CHEMBL3729264 | — | — | 1 | 7.60 |
| CHEMBL3732909 | — | — | 1 | 7.57 |
| CHEMBL3727382 | — | — | 1 | 7.55 |
| CHEMBL3732309 | — | — | 1 | 7.52 |
| CHEMBL3731936 | — | — | 1 | 7.51 |
| CHEMBL3731366 | — | — | 1 | 7.48 |
| CHEMBL3731764 | — | — | 1 | 7.48 |
| CHEMBL3728949 | — | — | 1 | 7.38 |
| CHEMBL3733189 | — | — | 1 | 7.38 |
| CHEMBL3732959 | — | — | 1 | 7.37 |
| CHEMBL3733173 | — | — | 1 | 7.35 |
| CHEMBL3730584 | — | — | 1 | 7.35 |
| CHEMBL3731980 | — | — | 1 | 7.35 |
| CHEMBL3728301 | — | — | 1 | 7.30 |
| CHEMBL3732382 | — | — | 1 | 7.26 |
| CHEMBL3729278 | — | — | 1 | 7.23 |
| CHEMBL3730477 | — | — | 1 | 7.21 |
| CHEMBL3730649 | — | — | 1 | 7.21 |
| CHEMBL3733102 | — | — | 1 | 7.20 |
| CHEMBL3729724 | — | — | 1 | 7.17 |
| CHEMBL3731231 | — | — | 1 | 7.15 |
| CHEMBL3731419 | — | — | 1 | 7.09 |
| CHEMBL3730174 | — | — | 1 | 7.09 |
| CHEMBL3730205 | — | — | 1 | 7.04 |
| CHEMBL3729891 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3731399 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3732843 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3728821 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3730913 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3731410 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3729264 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3732909 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3727382 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3732309 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3731936 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3731366 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3731764 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3728949 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3733189 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3732959 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3733173 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3731980 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3730584 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3728301 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3732382 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3729278 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3730477 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3730649 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3733102 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3729724 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3731231 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3730174 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3731419 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3730205 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3729891 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3730868 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3729489 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL3732409 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3729478 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3731305 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL3731744 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3732414 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3732154 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL3733209 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL3732768 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3727897 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3729611 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3727954 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3732185 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3728501 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL3729987 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL3729871 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL3732208 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL3728453 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL3732421 | — | IC50 | = | 273.0 | nM | 6.56 |