Assay Detail
Binding
CHEMBL3734301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PI3Kgamma activation incubated for 16 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 (CHEMBL3883319) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Compositions and methods for inhibiting g protein signaling
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.07 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1208090 | — | — | 1 | 5.60 |
| CHEMBL1208442 | — | — | 1 | 5.22 |
| CHEMBL487046 | — | — | 1 | 5.10 |
| CHEMBL471225 | — | — | 1 | 5.00 |
| CHEMBL203722 | — | — | 1 | 4.92 |
| CHEMBL1594881 | — | — | 1 | 4.87 |
| CHEMBL1529609 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1208090 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1208442 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL487046 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL471225 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL203722 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1594881 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1529609 | — | IC50 | = | 16000.0 | nM | 4.80 |