Compound Detail
CHEMBL1208090
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Basic Information
| ChEMBL ID | CHEMBL1208090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZCQMYMXRGJWSHH-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
2.62
ALogP
7
HBA
4
HBD
152.6
PSA (Ų)
0.30
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 CHEMBL3883319 | IC50 | 5.6 | 4.89 | 2500.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 | IC50 | = | 2500.0 | nM | 5.6 | Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PI3Kgamma acti... | - |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of SIGKAFKILGYPDYD binding to biotinylated Gbeta1gamma2 (unknown orig... | - |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 | IC50 | = | 12000.0 | nM | 4.92 | Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PLCbeta3 activ... | - |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 | IC50 | = | 75000.0 | nM | 4.12 | Inhibition of biotinylated Gbeta1gamma2 (unknown origin)-mediated PLCbeta2 activ... | - |
Data from ChEMBL 36 via Core Engine