Assay Detail
Functional
CHEMBL3734550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at MrgX1 in mouse or rat DRG neurons assessed as action potential by whole-cell patch clamp method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X1 (CHEMBL3341575) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Methods and compositions for treating or preventing pruritis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.36 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3730717 | — | — | 1 | 6.26 |
| CHEMBL3343995 | — | — | 1 | 6.14 |
| CHEMBL3730405 | — | — | 1 | 5.66 |
| CHEMBL3731811 | — | — | 1 | 5.66 |
| CHEMBL3727438 | — | — | 1 | 5.55 |
| CHEMBL3730599 | — | — | 1 | 5.44 |
| CHEMBL3727861 | — | — | 1 | 5.32 |
| CHEMBL3730179 | — | — | 1 | 5.28 |
| CHEMBL3728505 | — | — | 1 | 5.28 |
| CHEMBL145103 | — | — | 1 | 5.25 |
| CHEMBL3732603 | — | — | 1 | 5.20 |
| CHEMBL3730500 | — | — | 1 | 5.17 |
| CHEMBL3731844 | — | — | 1 | 5.06 |
| CHEMBL3729794 | — | — | 1 | 5.00 |
| CHEMBL3728009 | — | — | 1 | 4.87 |
| CHEMBL3733177 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3730717 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3343995 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3730405 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3731811 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3727438 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3730599 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3727861 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3730179 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3728505 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL145103 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3732603 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3730500 | — | IC50 | = | 6782.0 | nM | 5.17 |
| CHEMBL3731844 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3729794 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3728009 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3733177 | — | IC50 | = | 29000.0 | nM | 4.54 |