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Assay Detail

CHEMBL3734552

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Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL ↗
422
Total Activities
413
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

N-formyl peptide receptor 2 (CHEMBL4227) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
(2012)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 422 7.20 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3730217 — — 1 10.15
CHEMBL3728769 — — 1 10.00
CHEMBL3729012 — — 1 9.89
CHEMBL3727613 — — 1 9.80
CHEMBL3728932 — — 1 9.70
CHEMBL3729214 — — 1 9.62
CHEMBL3730056 — — 1 9.52
CHEMBL3730438 — — 1 9.47
CHEMBL3730133 — — 1 9.46
CHEMBL3731671 — — 1 9.46
CHEMBL3729434 — — 1 9.40
CHEMBL3732621 — — 1 9.39
CHEMBL3731259 — — 1 9.35
CHEMBL3731107 — — 1 9.35
CHEMBL3730874 — — 1 9.34
CHEMBL3727601 — — 1 9.30
CHEMBL3728644 — — 1 9.28
CHEMBL3731166 — — 1 9.26
CHEMBL3728245 — — 2 9.21
CHEMBL3729460 — — 1 9.18
CHEMBL3732081 — — 1 9.15
CHEMBL3730159 — — 1 9.14
CHEMBL3731113 — — 1 9.09
CHEMBL3732902 — — 1 9.06
CHEMBL3731635 — — 1 9.05
CHEMBL3729013 — — 1 9.03
CHEMBL3729228 — — 1 9.01
CHEMBL3731461 — — 1 9.00
CHEMBL3729246 — — 1 9.00
CHEMBL3731163 — — 2 8.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3730217 — EC50 = 0.07 nM 10.15
CHEMBL3728769 — EC50 = 0.1 nM 10.00
CHEMBL3729012 — EC50 = 0.13 nM 9.89
CHEMBL3727613 — EC50 = 0.16 nM 9.80
CHEMBL3728932 — EC50 = 0.2 nM 9.70
CHEMBL3729214 — EC50 = 0.24 nM 9.62
CHEMBL3730056 — EC50 = 0.3 nM 9.52
CHEMBL3730438 — EC50 = 0.34 nM 9.47
CHEMBL3731671 — EC50 = 0.35 nM 9.46
CHEMBL3730133 — EC50 = 0.35 nM 9.46
CHEMBL3729434 — EC50 = 0.4 nM 9.40
CHEMBL3732621 — EC50 = 0.41 nM 9.39
CHEMBL3731107 — EC50 = 0.45 nM 9.35
CHEMBL3731259 — EC50 = 0.45 nM 9.35
CHEMBL3730874 — EC50 = 0.46 nM 9.34
CHEMBL3727601 — EC50 = 0.5 nM 9.30
CHEMBL3728644 — EC50 = 0.53 nM 9.28
CHEMBL3731166 — EC50 = 0.55 nM 9.26
CHEMBL3728245 — EC50 = 0.61 nM 9.21
CHEMBL3729460 — EC50 = 0.66 nM 9.18
CHEMBL3732081 — EC50 = 0.7 nM 9.15
CHEMBL3730159 — EC50 = 0.72 nM 9.14
CHEMBL3731113 — EC50 = 0.82 nM 9.09
CHEMBL3732902 — EC50 = 0.87 nM 9.06
CHEMBL3731635 — EC50 = 0.89 nM 9.05
CHEMBL3729013 — EC50 = 0.94 nM 9.03
CHEMBL3729228 — EC50 = 0.98 nM 9.01
CHEMBL3729246 — EC50 = 1.0 nM 9.00
CHEMBL3731461 — EC50 = 1.0 nM 9.00
CHEMBL3731163 — EC50 = 1.1 nM 8.96
CHEMBL3731849 — EC50 = 1.1 nM 8.96
CHEMBL3730197 — EC50 = 1.2 nM 8.92
CHEMBL3730330 — EC50 = 1.3 nM 8.89
CHEMBL3732566 — EC50 = 1.3 nM 8.89
CHEMBL3728245 — EC50 = 1.3 nM 8.89
CHEMBL3731889 — EC50 = 1.3 nM 8.89
CHEMBL3729500 — EC50 = 1.3 nM 8.89
CHEMBL3731163 — EC50 = 1.4 nM 8.85
CHEMBL3732404 — EC50 = 1.4 nM 8.85
CHEMBL3728573 — EC50 = 1.4 nM 8.85
CHEMBL3729487 — EC50 = 1.5 nM 8.82
CHEMBL3727408 — EC50 = 1.6 nM 8.80
CHEMBL3731167 — EC50 = 1.8 nM 8.74
CHEMBL3728559 — EC50 = 1.8 nM 8.74
CHEMBL3733012 — EC50 = 1.8 nM 8.74
CHEMBL3728297 — EC50 = 2.0 nM 8.70
CHEMBL3733084 — EC50 = 2.0 nM 8.70
CHEMBL3728238 — EC50 = 2.1 nM 8.68
CHEMBL3729758 — EC50 = 2.1 nM 8.68
CHEMBL3729130 — EC50 = 2.1 nM 8.68