Assay Detail
Binding
CHEMBL3736682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9/Cyclin-T1 (unknown origin) using UlightCFFKNIVTPRTPPPSQGK-amide substrate after 90 mins by autoradiography
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.93 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.34 |
| CHEMBL3734879 | — | — | 1 | 6.48 |
| CHEMBL3735502 | — | — | 1 | 6.11 |
| CHEMBL3735818 | — | — | 1 | 5.76 |
| CHEMBL3735561 | — | — | 1 | 5.70 |
| CHEMBL3735231 | — | — | 1 | 5.61 |
| CHEMBL3735656 | — | — | 1 | 5.59 |
| CHEMBL3735432 | — | — | 1 | 4.95 |
| CHEMBL3735063 | — | — | 1 | 4.81 |
| CHEMBL3735072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 4.59 | nM | 8.34 |
| CHEMBL3734879 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3735502 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3735818 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3735561 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL3735231 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL3735656 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL3735432 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3735063 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL3735072 | — | IC50 | > | 10000.0 | nM | - |