Assay Detail
Binding
CHEMBL3737377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from Glun2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by scintillation counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.24 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735947 | — | — | 1 | 8.80 |
| CHEMBL3735485 | — | — | 1 | 8.48 |
| CHEMBL3736502 | — | — | 1 | 8.42 |
| CHEMBL3735173 | — | — | 1 | 8.12 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 8.00 |
| CHEMBL3357784 | — | — | 1 | 8.00 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735947 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3735485 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL3736502 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3735173 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3357784 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL28564 | ELIPRODIL | Ki | = | 13.0 | nM | 7.89 |