Assay Detail
Functional
CHEMBL3737772
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Vasodilative activity in isolated Sprague-Dawley rat coronary artery assessed as reduction in KCl-induced contraction by wire myograph method relative to control
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Coronary artery |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of novel 2-benzylisoquinolin-1(2H)-ones as potent vasodilative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 1 | - | - |
| EC50 | 1 | 5.70 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735483 | — | — | 2 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735483 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL3735483 | — | Emax | = | 107.3 | % | - |