Assay Detail
Binding
CHEMBL3737962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR T790M/del (746 to 750) deletion mutant phosphorylation in erlotinib-resistant human PC9 cells preincubated for 1 hr followed by stimulation with EGF for 8 mins by electrochemiluminescent immunoassay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.33 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3736121 | — | — | 1 | 7.57 |
| CHEMBL3734988 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3736121 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3734988 | — | IC50 | = | 81.0 | nM | 7.09 |