Assay Detail
Functional
CHEMBL3737981
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Growth inhibition of mouse BA/F3 cells expressing wild-type Bcr-Abl after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Alkyne-Containing Pyrazolopyrimidines To Overcome Drug Resistance of Bcr-Abl Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.17 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171086 | — | — | 1 | 9.40 |
| CHEMBL3736320 | — | — | 1 | 8.40 |
| CHEMBL3735207 | — | — | 1 | 8.05 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.05 |
| CHEMBL3735312 | — | — | 1 | 6.58 |
| CHEMBL1213120 | — | — | 1 | 6.43 |
| CHEMBL3736466 | — | — | 1 | 6.20 |
| CHEMBL2058540 | — | — | 1 | 5.85 |
| CHEMBL3736306 | — | — | 1 | 5.61 |
| CHEMBL2058538 | — | — | 1 | 5.30 |
| CHEMBL3734967 | — | — | 1 | 5.28 |
| CHEMBL3736026 | — | — | 1 | 5.01 |
| CHEMBL3735576 | — | — | 1 | 4.97 |
| CHEMBL3735795 | — | — | 1 | 4.96 |
| CHEMBL3735491 | — | — | 1 | 4.88 |
| CHEMBL3734907 | — | — | 1 | 4.76 |
| CHEMBL3735380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171086 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3736320 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3735207 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL941 | IMATINIB | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3735312 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1213120 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL3736466 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL2058540 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3736306 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL2058538 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL3734967 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3736026 | — | IC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL3735576 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3735795 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3735491 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3734907 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3735380 | — | IC50 | > | 30000.0 | nM | - |