Assay Detail
Functional
CHEMBL3737994
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Growth inhibition of mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Alkyne-Containing Pyrazolopyrimidines To Overcome Drug Resistance of Bcr-Abl Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.02 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171086 | — | — | 1 | 9.52 |
| CHEMBL3736320 | — | — | 1 | 8.22 |
| CHEMBL3735207 | — | — | 1 | 7.80 |
| CHEMBL1213120 | — | — | 1 | 7.15 |
| CHEMBL3736466 | — | — | 1 | 6.29 |
| CHEMBL3735312 | — | — | 1 | 6.06 |
| CHEMBL2058540 | — | — | 1 | 5.85 |
| CHEMBL3736306 | — | — | 1 | 5.37 |
| CHEMBL2058538 | — | — | 1 | 5.35 |
| CHEMBL3735795 | — | — | 1 | 5.28 |
| CHEMBL3736026 | — | — | 1 | 5.25 |
| CHEMBL3734967 | — | — | 1 | 5.00 |
| CHEMBL3735491 | — | — | 1 | 4.91 |
| CHEMBL3735576 | — | — | 1 | 4.84 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.84 |
| CHEMBL3734907 | — | — | 1 | 4.57 |
| CHEMBL3735380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171086 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3736320 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3735207 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1213120 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3736466 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3735312 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL2058540 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3736306 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL2058538 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3735795 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3736026 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL3734967 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3735491 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL3735576 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL941 | IMATINIB | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3734907 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3735380 | — | IC50 | > | 30000.0 | nM | - |