Assay Detail
Binding
CHEMBL3738446
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Agonist activity at mu opioid receptor in Hartley guniea pig isolated ileum assessed as inhibition of electrically-stimulated muscle contraction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.96 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4299371 | — | — | 1 | 7.68 |
| CHEMBL4299423 | — | — | 1 | 7.38 |
| CHEMBL4299479 | — | — | 1 | 7.19 |
| CHEMBL4299415 | — | — | 1 | 7.11 |
| CHEMBL4299390 | — | — | 1 | 7.09 |
| CHEMBL4299483 | — | — | 1 | 6.78 |
| CHEMBL4299466 | — | — | 1 | 6.64 |
| CHEMBL438389 | — | — | 1 | 6.46 |
| CHEMBL4299476 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4299371 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4299423 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4299479 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4299415 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4299390 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4299483 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4299466 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL438389 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4299476 | — | IC50 | = | 460.0 | nM | 6.34 |