Assay Detail
Binding
CHEMBL3738517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus ATCC 35556 SecA1 liposomal ion channel activity in Xenopus laevis oocytes incubated for 3 hrs measured by recording ion current for 1 min
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein translocase subunit SecA 1 (CHEMBL3832949) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain NCTC 8325) |
Publication
Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.00 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2359093 | ROSE BENGAL SODIUM | 2.0 | 1 | 6.30 |
| CHEMBL3735815 | — | — | 1 | 6.00 |
| CHEMBL3736159 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2359093 | ROSE BENGAL SODIUM | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3735815 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3736159 | — | IC50 | = | 2000.0 | nM | 5.70 |