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Assay Detail

CHEMBL3738596

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Functional
Cytotoxicity against human PANC1 cells by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PANC-1
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and biological evaluation of novel derivatives of gambogenic acid as anticancer agents
Huang P, Hu Z, He L, Wang X, Wu Y
Medchemcomm (2015) 6 : 334 -338
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.56 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4299373 1 6.35
CHEMBL3735895 1 6.10
CHEMBL4299414 1 5.74
CHEMBL4299388 1 5.72
CHEMBL4299393 1 5.72
CHEMBL4299374 1 5.63
CHEMBL3736138 1 5.60
CHEMBL4299395 1 5.60
CHEMBL4299387 1 5.58
CHEMBL4299392 1 5.54
CHEMBL4299375 1 5.54
CHEMBL2205166 GAMBOGENIC ACID 1 5.38
CHEMBL4299420 1 5.35
CHEMBL4299394 1 5.33
CHEMBL4299398 1 5.12
CHEMBL4299413 1 4.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4299373 IC50 = 450.0 nM 6.35
CHEMBL3735895 IC50 = 790.0 nM 6.10
CHEMBL4299414 IC50 = 1840.0 nM 5.74
CHEMBL4299388 IC50 = 1890.0 nM 5.72
CHEMBL4299393 IC50 = 1890.0 nM 5.72
CHEMBL4299374 IC50 = 2360.0 nM 5.63
CHEMBL3736138 IC50 = 2510.0 nM 5.60
CHEMBL4299395 IC50 = 2520.0 nM 5.60
CHEMBL4299387 IC50 = 2610.0 nM 5.58
CHEMBL4299392 IC50 = 2860.0 nM 5.54
CHEMBL4299375 IC50 = 2850.0 nM 5.54
CHEMBL2205166 GAMBOGENIC ACID IC50 = 4160.0 nM 5.38
CHEMBL4299420 IC50 = 4430.0 nM 5.35
CHEMBL4299394 IC50 = 4660.0 nM 5.33
CHEMBL4299398 IC50 = 7570.0 nM 5.12
CHEMBL4299413 IC50 = 18580.0 nM 4.73