Assay Detail
Binding
CHEMBL3738915
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse plasma kallikrein for 15 mins using H-D-Pro-Phe-Arg-p-nitroanilide as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.90 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735513 | — | — | 1 | 7.57 |
| CHEMBL3735217 | — | — | 1 | 7.37 |
| CHEMBL3735263 | — | — | 1 | 7.30 |
| CHEMBL3735080 | — | — | 1 | 5.34 |
| CHEMBL3734777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735513 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3735217 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3735263 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3735080 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL3734777 | — | Ki | > | 1000000.0 | nM | - |