Compound Detail
CHEMBL3735513
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CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC2CCN(C(=N)N)CC2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CSSC[C@@H](C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL3735513 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | DAZKRYLEGWSBDU-RSOQHMFVSA-N |
7
Targets
7
Activities
1
Assay Types
1
PK Parameters
11
Publications
0
Known Names
Molecular Properties
1221.5
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 7 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasma kallikrein CHEMBL2000 | Ki | 8.1 | 8.1 | 8.0 | 1 |
| Plasma kallikrein CHEMBL1250359 | Ki | 7.57 | 7.57 | 27.0 | 1 |
| Kallikrein-1 CHEMBL2319 | Ki | 6.7 | 6.7 | 201.0 | 1 |
| Plasminogen CHEMBL1075299 | Ki | 5.53 | 5.53 | 2970.0 | 1 |
| Coagulation factor XI CHEMBL2820 | Ki | 5.4 | 5.4 | 3970.0 | 1 |
| Plasminogen CHEMBL1801 | Ki | 4.97 | 4.97 | 10600.0 | 1 |
| Serine protease 1 CHEMBL3769 | Ki | 4.74 | 4.74 | 18200.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 24.0 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasma kallikrein | Ki | = | 8.0 | nM | 8.1 | Inhibition of human plasma kallikrein for 15 mins using H-D-Pro-Phe-Arg-p-nitroa... | 26536069 |
| Plasma kallikrein | Ki | = | 27.0 | nM | 7.57 | Inhibition of mouse plasma kallikrein for 15 mins using H-D-Pro-Phe-Arg-p-nitroa... | 26536069 |
| Kallikrein-1 | Ki | = | 201.0 | nM | 6.7 | Inhibition of human KLK1 after 15 mins using Val-Leu-Lys-p-nitroanilide as subst... | 26536069 |
| Plasminogen | Ki | = | 2970.0 | nM | 5.53 | Inhibition of mouse plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide a... | 26536069 |
| Coagulation factor XI | Ki | = | 3970.0 | nM | 5.4 | Inhibition of human coagulation factor 11a after 15 mins | 26536069 |
| Plasminogen | Ki | = | 10600.0 | nM | 4.97 | Inhibition of human plasmin after 15 mins using H-D-Ile-Pro-Arg-p-nitroanilide a... | 26536069 |
| Serine protease 1 | Ki | = | 18200.0 | nM | 4.74 | Inhibition of bovine beta-trypsin after 15 mins using Bz-Ile-Glu(g-OR)-Gly-Arg-p... | 26536069 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Plasma kallikrein | 2 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Urokinase-type plasminogen activator | 2 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Plasminogen | 2 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Prothrombin | 2 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Tissue-type plasminogen activator | 2 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Serine protease 1 | 1 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Coagulation factor XI | 1 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Kallikrein-1 | 1 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Vitamin K-dependent protein C | 1 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Suppressor of tumorigenicity 14 protein | 1 |
| 26536069 | 10.1021/acs.jmedchem.5b01128 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine