Assay Detail
Binding
CHEMBL3738916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human uPA for 15 mins using pyro-Glu-Gly-Arg-p-nitroanilide as substrate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.03 | 4.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735080 | — | — | 1 | 4.03 |
| CHEMBL3734777 | — | — | 1 | - |
| CHEMBL3736473 | — | — | 1 | - |
| CHEMBL3735263 | — | — | 1 | - |
| CHEMBL3735513 | — | — | 1 | - |
| CHEMBL3735217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735080 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL3734777 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3736473 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3735263 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3735513 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL3735217 | — | Ki | > | 1000000.0 | nM | - |