Assay Detail
Functional
CHEMBL3739243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.20 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3734974 | — | — | 1 | 5.82 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.96 |
| CHEMBL512578 | MORACIN M | — | 1 | 4.82 |
| CHEMBL497 | CLIOQUINOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3734974 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL50 | QUERCETIN | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL512578 | MORACIN M | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL497 | CLIOQUINOL | EC50 | > | 30000.0 | nM | - |