Assay Detail
Binding
CHEMBL3742870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human GST-tagged TNF extracellular domain expressed in Escherichia coli BL21(DE3)pLysS cells by fluorescence spectrophotometric analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of potential small moleculeinhibitors of tumor necrosis factor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 41 | 5.09 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3740080 | — | — | 1 | 6.13 |
| CHEMBL3740051 | — | — | 1 | 6.02 |
| CHEMBL3741883 | — | — | 1 | 5.79 |
| CHEMBL3741027 | — | — | 1 | 5.67 |
| CHEMBL3742137 | — | — | 1 | 5.60 |
| CHEMBL3741275 | — | — | 1 | 5.50 |
| CHEMBL3741215 | — | — | 1 | 5.32 |
| CHEMBL3741778 | — | — | 1 | 5.29 |
| CHEMBL3740564 | — | — | 1 | 5.28 |
| CHEMBL3740334 | — | — | 1 | 5.26 |
| CHEMBL3741720 | — | — | 1 | 5.16 |
| CHEMBL3741926 | — | — | 1 | 5.11 |
| CHEMBL3741784 | — | — | 1 | 5.08 |
| CHEMBL3741761 | — | — | 1 | 5.00 |
| CHEMBL3740763 | — | — | 1 | 4.99 |
| CHEMBL3741962 | — | — | 1 | 4.97 |
| CHEMBL3742191 | — | — | 1 | 4.91 |
| CHEMBL3740702 | — | — | 1 | 4.89 |
| CHEMBL3742150 | — | — | 1 | 4.88 |
| CHEMBL3740948 | — | — | 1 | 4.85 |
| CHEMBL3739810 | — | — | 1 | 4.82 |
| CHEMBL3741278 | — | — | 1 | 4.81 |
| CHEMBL3741940 | — | — | 1 | 4.77 |
| CHEMBL3740629 | — | — | 1 | 4.76 |
| CHEMBL3740371 | — | — | 1 | 4.75 |
| CHEMBL3739952 | — | — | 1 | 4.73 |
| CHEMBL3740299 | — | — | 1 | 4.73 |
| CHEMBL3741286 | — | — | 1 | 4.60 |
| CHEMBL3741025 | — | — | 1 | 4.60 |
| CHEMBL3740423 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3740080 | — | Kd | = | 740.0 | nM | 6.13 |
| CHEMBL3740051 | — | Kd | = | 950.0 | nM | 6.02 |
| CHEMBL3741883 | — | Kd | = | 1610.0 | nM | 5.79 |
| CHEMBL3741027 | — | Kd | = | 2140.0 | nM | 5.67 |
| CHEMBL3742137 | — | Kd | = | 2510.0 | nM | 5.60 |
| CHEMBL3741275 | — | Kd | = | 3160.0 | nM | 5.50 |
| CHEMBL3741215 | — | Kd | = | 4780.0 | nM | 5.32 |
| CHEMBL3741778 | — | Kd | = | 5120.0 | nM | 5.29 |
| CHEMBL3740564 | — | Kd | = | 5200.0 | nM | 5.28 |
| CHEMBL3740334 | — | Kd | = | 5450.0 | nM | 5.26 |
| CHEMBL3741720 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL3741926 | — | Kd | = | 7820.0 | nM | 5.11 |
| CHEMBL3741784 | — | Kd | = | 8220.0 | nM | 5.08 |
| CHEMBL3741761 | — | Kd | = | 10120.0 | nM | 5.00 |
| CHEMBL3740763 | — | Kd | = | 10330.0 | nM | 4.99 |
| CHEMBL3741962 | — | Kd | = | 10740.0 | nM | 4.97 |
| CHEMBL3742191 | — | Kd | = | 12220.0 | nM | 4.91 |
| CHEMBL3740702 | — | Kd | = | 12810.0 | nM | 4.89 |
| CHEMBL3742150 | — | Kd | = | 13280.0 | nM | 4.88 |
| CHEMBL3740948 | — | Kd | = | 14120.0 | nM | 4.85 |
| CHEMBL3739810 | — | Kd | = | 15170.0 | nM | 4.82 |
| CHEMBL3741278 | — | Kd | = | 15610.0 | nM | 4.81 |
| CHEMBL3741940 | — | Kd | = | 16820.0 | nM | 4.77 |
| CHEMBL3740629 | — | Kd | = | 17270.0 | nM | 4.76 |
| CHEMBL3740371 | — | Kd | = | 17850.0 | nM | 4.75 |
| CHEMBL3739952 | — | Kd | = | 18640.0 | nM | 4.73 |
| CHEMBL3740299 | — | Kd | = | 18750.0 | nM | 4.73 |
| CHEMBL3741286 | — | Kd | = | 25030.0 | nM | 4.60 |
| CHEMBL3741025 | — | Kd | = | 25360.0 | nM | 4.60 |
| CHEMBL3740423 | — | Kd | = | 35230.0 | nM | 4.45 |
| CHEMBL3741437 | — | Kd | > | 35000.0 | nM | - |
| CHEMBL3740816 | — | Kd | - | — | - | |
| CHEMBL3740927 | — | Kd | - | — | - | |
| CHEMBL3740630 | — | Kd | - | — | - | |
| CHEMBL3740824 | — | Kd | - | — | - | |
| CHEMBL3741922 | — | Kd | > | 35000.0 | nM | - |
| CHEMBL3741015 | — | Kd | - | — | - | |
| CHEMBL3739774 | — | Kd | - | — | - | |
| CHEMBL3741299 | — | Kd | - | — | - | |
| CHEMBL3739428 | — | Kd | - | — | - | |
| CHEMBL3740193 | — | Kd | - | — | - |