Assay Detail
Binding
CHEMBL3742873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human TNF assessed as inhibition of TNF-TNFR1 interaction incubated for 1 hr by ELISA
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of potential small moleculeinhibitors of tumor necrosis factor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.64 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255489 | — | — | 1 | 5.30 |
| CHEMBL3739952 | — | — | 1 | 5.00 |
| CHEMBL3741761 | — | — | 1 | 4.82 |
| CHEMBL3741215 | — | — | 1 | 4.82 |
| CHEMBL3740080 | — | — | 1 | 4.70 |
| CHEMBL3741027 | — | — | 1 | 4.70 |
| CHEMBL3741883 | — | — | 1 | 4.70 |
| CHEMBL3740948 | — | — | 1 | 4.70 |
| CHEMBL3740051 | — | — | 1 | 4.70 |
| CHEMBL3740564 | — | — | 1 | 4.40 |
| CHEMBL3741926 | — | — | 1 | 4.40 |
| CHEMBL3740702 | — | — | 1 | 4.40 |
| CHEMBL3740334 | — | — | 1 | 4.40 |
| CHEMBL3741278 | — | — | 1 | 4.40 |
| CHEMBL3741940 | — | — | 1 | 4.40 |
| CHEMBL3741275 | — | — | 1 | 4.40 |
| CHEMBL3740927 | — | — | 1 | - |
| CHEMBL3740816 | — | — | 1 | - |
| CHEMBL3741437 | — | — | 1 | - |
| CHEMBL3739810 | — | — | 1 | - |
| CHEMBL3742150 | — | — | 1 | - |
| CHEMBL3739774 | — | — | 1 | - |
| CHEMBL3740763 | — | — | 1 | - |
| CHEMBL3740299 | — | — | 1 | - |
| CHEMBL3741015 | — | — | 1 | - |
| CHEMBL3740371 | — | — | 1 | - |
| CHEMBL3741962 | — | — | 1 | - |
| CHEMBL3741299 | — | — | 1 | - |
| CHEMBL3739428 | — | — | 1 | - |
| CHEMBL3740193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255489 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3739952 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3741761 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3741215 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3740080 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3741027 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3741883 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3740948 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3740051 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3741926 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3740564 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3740702 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3740334 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3741275 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3741278 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3741940 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3740927 | — | IC50 | - | — | - | |
| CHEMBL3741784 | — | IC50 | - | — | - | |
| CHEMBL3740630 | — | IC50 | - | — | - | |
| CHEMBL3740824 | — | IC50 | - | — | - | |
| CHEMBL3740629 | — | IC50 | - | — | - | |
| CHEMBL3741286 | — | IC50 | - | — | - | |
| CHEMBL3741922 | — | IC50 | - | — | - | |
| CHEMBL3741720 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL3740423 | — | IC50 | - | — | - | |
| CHEMBL3741025 | — | IC50 | - | — | - | |
| CHEMBL3742191 | — | IC50 | - | — | - | |
| CHEMBL3741778 | — | IC50 | - | — | - | |
| CHEMBL3742137 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL3740816 | — | IC50 | - | — | - | |
| CHEMBL3741437 | — | IC50 | - | — | - | |
| CHEMBL3739810 | — | IC50 | - | — | - | |
| CHEMBL3742150 | — | IC50 | - | — | - | |
| CHEMBL3739774 | — | IC50 | - | — | - | |
| CHEMBL3740763 | — | IC50 | - | — | - | |
| CHEMBL3740299 | — | IC50 | - | — | - | |
| CHEMBL3741015 | — | IC50 | - | — | - | |
| CHEMBL3740371 | — | IC50 | - | — | - | |
| CHEMBL3741962 | — | IC50 | - | — | - | |
| CHEMBL3741299 | — | IC50 | - | — | - | |
| CHEMBL3739428 | — | IC50 | - | — | - | |
| CHEMBL3740193 | — | IC50 | - | — | - |