Assay Detail
Functional
CHEMBL3743176
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Antiproliferative activity against human DU145 cells assessed as reduction in cell viability after 24 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel indole-based sigma-2 receptor ligands: synthesis, structureaffinity relationship and antiproliferative activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.66 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 4.86 |
| CHEMBL3739449 | — | — | 1 | 4.57 |
| CHEMBL3354882 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61479 | SIRAMESINE | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3739449 | — | EC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL3354882 | — | EC50 | = | 28800.0 | nM | 4.54 |