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Assay Detail

CHEMBL3743263

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60 cells after 120 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation.
Januchta W, Serocki M, Dzierzbicka K, Cholewiński G, Skladanowski A.
Eur J Med Chem (2015) 106 : 85 -94
PubMed 26520842 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.68 5.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3739938 1 5.33
CHEMBL3742223 1 5.28
CHEMBL3742197 1 4.96
CHEMBL3741811 1 4.96
CHEMBL3742306 1 4.81
CHEMBL3740735 1 4.71
CHEMBL3740622 1 4.54
CHEMBL3740570 1 4.51
CHEMBL114283 DANIQUIDONE 2.0 1 4.18
CHEMBL3740525 1 4.11
CHEMBL3739565 1 4.08
CHEMBL3739772 1 -
CHEMBL3740049 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3739938 IC50 = 4700.0 nM 5.33
CHEMBL3742223 IC50 = 5300.0 nM 5.28
CHEMBL3742197 IC50 = 11000.0 nM 4.96
CHEMBL3741811 IC50 = 11100.0 nM 4.96
CHEMBL3742306 IC50 = 15400.0 nM 4.81
CHEMBL3740735 IC50 = 19600.0 nM 4.71
CHEMBL3740622 IC50 = 28700.0 nM 4.54
CHEMBL3740570 IC50 = 30800.0 nM 4.51
CHEMBL114283 DANIQUIDONE IC50 = 66600.0 nM 4.18
CHEMBL3740525 IC50 = 77300.0 nM 4.11
CHEMBL3739565 IC50 = 83700.0 nM 4.08
CHEMBL3739772 IC50 > 100000.0 nM -
CHEMBL3740049 IC50 > 100000.0 nM -