Assay Detail
Binding
CHEMBL3743974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine pancreatic trypsin using Nalpha-benzoyl-D,L-Arg-pNA-HCl as substrate measured for 5 mins by spectrophotometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.05 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945236 | — | — | 1 | 5.50 |
| CHEMBL87563 | GABEXATE | 3.0 | 1 | 5.15 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 4.50 |
| CHEMBL3740183 | — | — | 1 | - |
| CHEMBL3740931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945236 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL87563 | GABEXATE | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL945 | AMILORIDE | IC50 | = | 31760.0 | nM | 4.50 |
| CHEMBL3740183 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3740931 | — | IC50 | = | 114880.0 | nM | - |